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| 09.04.2022 | 11:00 | FC Viktoria 1889 Berlin | - | Werder Bremen | 4:1 (2:0) | |
| 11:00 | Eimsbütteler TV | - | 1. FC Magdeburg | 1:1 (0:1) | ||
| 11:00 | VfL Osnabrück | - | Energie Cottbus | 2:0 (0:0) | ||
| 11:00 | FC Carl Zeiss Jena | - | Hamburger SV | 0:5 (0:2) | ||
| 12:00 | RB Leipzig | - | Hannover 96 | 2:0 (2:0) | ||
| 13:00 | Dynamo Dresden | - | Hertha BSC | 1:1 (1:0) | ||
| 13:30 | Hallescher FC | - | VfL Wolfsburg | 0:1 (0:1) | ||
| 16:00 | Chemnitzer FC | - | 1. FC Union Berlin | 0:2 (0:0) | ||
| 10.04.2022 | 14:00 | Holstein Kiel | - | Hansa Rostock | 0:2 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 16 | 12 | 2 | 2 | 43:21 | 22 | 38 |
| 2 |
|
Energie Cottbus | 16 | 11 | 2 | 3 | 29:17 | 12 | 35 |
| 3 |
|
RB Leipzig | 16 | 10 | 3 | 3 | 40:18 | 22 | 33 |
| 4 |
|
Werder Bremen | 16 | 10 | 1 | 5 | 40:33 | 7 | 31 |
| 5 |
|
Holstein Kiel | 16 | 9 | 2 | 5 | 25:23 | 2 | 29 |
| 6 |
|
FC Viktoria 1889 Berlin | 16 | 7 | 6 | 3 | 29:19 | 10 | 27 |
| 7 |
|
VfL Wolfsburg | 17 | 7 | 5 | 5 | 21:20 | 1 | 26 |
| 8 |
|
1. FC Union Berlin | 16 | 7 | 4 | 5 | 25:23 | 2 | 25 |
| 9 |
|
Hamburger SV | 16 | 6 | 4 | 6 | 31:30 | 1 | 22 |
| 10 |
|
Hansa Rostock | 16 | 6 | 3 | 7 | 29:21 | 8 | 21 |
| 11 |
|
1. FC Magdeburg | 16 | 6 | 2 | 8 | 31:27 | 4 | 20 |
| 12 |
|
Dynamo Dresden | 16 | 6 | 2 | 8 | 23:20 | 3 | 20 |
| 13 |
|
Hannover 96 | 16 | 5 | 4 | 7 | 20:22 | -2 | 19 |
| 14 |
|
VfL Osnabrück | 16 | 5 | 4 | 7 | 19:28 | -9 | 19 |
| 15 |
|
Hallescher FC | 16 | 5 | 3 | 8 | 15:30 | -15 | 18 |
| 16 |
|
Chemnitzer FC | 16 | 4 | 4 | 8 | 16:27 | -11 | 16 |
| 17 |
|
FC St. Pauli | 16 | 4 | 3 | 9 | 23:35 | -12 | 15 |
| 18 |
|
Eimsbütteler TV | 16 | 2 | 4 | 10 | 15:33 | -18 | 10 |
| 19 |
|
FC Carl Zeiss Jena | 17 | 1 | 2 | 14 | 12:39 | -27 | 5 |
| Playoffs | |
| Abstieg |
