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| 09.04.2022 | 02:10 | Atlético Rafaela | - | Alvarado | 4:0 (3:0) | |
| 20:30 | Agropecuario Argentino | - | Mitre de SdE | 2:0 (1:0) | ||
| 20:30 | All Boys | - | Villa Dálmine | 2:2 (1:0) | ||
| 20:30 | Atlanta | - | Deportivo Morón | 1:1 (0:0) | ||
| 21:30 | San Martín de San Juan | - | Temperley | 4:1 (2:1) | ||
| 21:30 | Gimnasia de Mendoza | - | Almirante Brown | 1:0 (0:0) | ||
| 23:10 | Estudiantes de Caseros | - | Deportivo Madryn | 0:0 (0:0) | ||
| 10.04.2022 | 16:00 | Brown de Adrogué | - | Deportivo Maipú | 1:2 (0:1) | |
| 19:40 | Instituto de Córdoba | - | Sacachispas | 1:0 (1:0) | ||
| 20:30 | Tristan Suárez | - | Ferro Carril Oeste | 0:0 (0:0) | ||
| 20:30 | Guillermo Brown | - | Almagro | 0:1 (0:0) | ||
| 20:30 | San Telmo | - | Gimnasia de Jujuy | 0:0 (0:0) | ||
| 21:40 | Chacarita Juniors | - | Nueva Chicago | 3:1 (1:1) | ||
| 23:00 | Chaco For Ever | - | Flandria | 2:2 (1:1) | ||
| 11.04.2022 | 22:05 | Defensores de Belgrano | - | Quilmes | 1:0 (1:0) | |
| 12.04.2022 | 00:10 | Güemes de SdE | - | Belgrano de Córdoba | 0:1 (0:0) | |
| 01:30 | Ramón Santamarina | - | Estudiantes de Río Cuarto | 1:1 (0:1) | ||
| 02:10 | San Martín de Tucumán | - | Independiente Rivadavia | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 10 | 8 | 1 | 1 | 15:7 | 8 | 25 |
| 2 |
|
San Martín de Tucumán | 10 | 6 | 3 | 1 | 14:7 | 7 | 21 |
| 3 |
|
Instituto de Córdoba | 10 | 5 | 5 | 0 | 12:7 | 5 | 20 |
| 4 |
|
Brown de Adrogué | 10 | 5 | 4 | 1 | 16:8 | 8 | 19 |
| 5 |
|
Chacarita Juniors | 10 | 5 | 2 | 3 | 18:13 | 5 | 17 |
| 6 |
|
Deportivo Riestra | 9 | 4 | 5 | 0 | 7:2 | 5 | 17 |
| 7 |
|
Almirante Brown | 10 | 4 | 4 | 2 | 12:10 | 2 | 16 |
| 8 |
|
Deportivo Maipú | 10 | 4 | 4 | 2 | 11:9 | 2 | 16 |
| 9 |
|
Guillermo Brown | 10 | 5 | 1 | 4 | 9:8 | 1 | 16 |
| 10 |
|
Defensores de Belgrano | 10 | 4 | 3 | 3 | 11:11 | 0 | 15 |
| 11 |
|
Atlanta | 10 | 3 | 5 | 2 | 12:8 | 4 | 14 |
| 12 |
|
All Boys | 9 | 3 | 5 | 1 | 12:9 | 3 | 14 |
| 13 |
|
Chaco For Ever | 10 | 2 | 8 | 0 | 11:8 | 3 | 14 |
| 14 |
|
Deportivo Madryn | 10 | 3 | 5 | 2 | 10:8 | 2 | 14 |
| 15 |
|
Estudiantes de Caseros | 10 | 3 | 5 | 2 | 8:7 | 1 | 14 |
| 16 |
|
Estudiantes de Río Cuarto | 10 | 3 | 5 | 2 | 8:8 | 0 | 14 |
| 17 |
|
San Martín de San Juan | 10 | 4 | 1 | 5 | 13:11 | 2 | 13 |
| 18 |
|
Agropecuario Argentino | 10 | 3 | 4 | 3 | 11:9 | 2 | 13 |
| 19 |
|
Almagro | 10 | 4 | 1 | 5 | 8:13 | -5 | 13 |
| 20 |
|
Gimnasia de Mendoza | 9 | 3 | 3 | 3 | 11:6 | 5 | 12 |
| 21 |
|
Atlético Rafaela | 10 | 3 | 3 | 4 | 11:8 | 3 | 12 |
| 22 |
|
Quilmes | 9 | 2 | 5 | 2 | 11:10 | 1 | 11 |
| 23 |
|
Deportivo Morón | 10 | 2 | 5 | 3 | 6:6 | 0 | 11 |
| 24 |
|
Nueva Chicago | 10 | 2 | 5 | 3 | 9:11 | -2 | 11 |
| 25 |
|
Independiente Rivadavia | 9 | 3 | 2 | 4 | 8:11 | -3 | 11 |
| 26 |
|
Gimnasia de Jujuy | 10 | 2 | 5 | 3 | 9:13 | -4 | 11 |
| 27 |
|
Alvarado | 10 | 2 | 4 | 4 | 10:18 | -8 | 10 |
| 28 |
|
Sacachispas | 9 | 1 | 6 | 2 | 9:9 | 0 | 9 |
| 29 |
|
Flandria | 10 | 2 | 3 | 5 | 13:16 | -3 | 9 |
| 30 |
|
Ferro Carril Oeste | 9 | 1 | 5 | 3 | 8:10 | -2 | 8 |
| 31 |
|
Temperley | 10 | 2 | 2 | 6 | 9:14 | -5 | 8 |
| 32 |
|
Villa Dálmine | 10 | 1 | 5 | 4 | 11:19 | -8 | 8 |
| 33 |
|
San Telmo | 9 | 1 | 5 | 3 | 5:13 | -8 | 8 |
| 34 |
|
Tristan Suárez | 10 | 0 | 7 | 3 | 12:15 | -3 | 7 |
| 35 |
|
Ramón Santamarina | 10 | 1 | 4 | 5 | 10:14 | -4 | 7 |
| 36 |
|
Mitre de SdE | 9 | 0 | 4 | 5 | 5:12 | -7 | 4 |
| 37 |
|
Güemes de SdE | 9 | 0 | 4 | 5 | 4:11 | -7 | 4 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
