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| 21.05.2022 | 00:10 | Atlanta | - | Deportivo Maipú | 0:0 (0:0) | |
| 02:00 | All Boys | - | Deportivo Madryn | 1:1 (1:0) | ||
| 02:10 | Belgrano de Córdoba | - | Flandria | 2:0 (1:0) | ||
| 20:10 | Brown de Adrogué | - | Instituto de Córdoba | 2:1 (0:0) | ||
| 20:10 | Defensores de Belgrano | - | Agropecuario Argentino | 0:0 (0:0) | ||
| 20:30 | Ramón Santamarina | - | Independiente Rivadavia | 0:3 (0:1) | ||
| 20:30 | Villa Dálmine | - | Gimnasia de Jujuy | 3:0 (1:0) | ||
| 21:00 | San Martín de San Juan | - | Nueva Chicago | 3:1 (1:1) | ||
| 22.05.2022 | 00:10 | Estudiantes de Caseros | - | Quilmes | 2:1 (1:1) | |
| 19:00 | Guillermo Brown | - | Mitre de SdE | 2:1 (2:0) | ||
| 19:00 | San Telmo | - | Alvarado | 0:1 (0:0) | ||
| 21:00 | Atlético Rafaela | - | Ferro Carril Oeste | 0:1 (0:0) | ||
| 21:00 | Gimnasia de Mendoza | - | Estudiantes de Río Cuarto | 2:0 (1:0) | ||
| 22:00 | Chacarita Juniors | - | Sacachispas | 0:1 (0:1) | ||
| 23.05.2022 | 00:00 | Güemes de SdE | - | Deportivo Morón | 0:0 (0:0) | |
| 02:30 | San Martín de Tucumán | - | Tristan Suárez | 1:0 (1:0) | ||
| 20:35 | Deportivo Riestra | - | Temperley | 1:2 (1:1) | ||
| 24.05.2022 | 02:10 | Chaco For Ever | - | Almagro | 0:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 15 | 12 | 1 | 2 | 21:9 | 12 | 37 |
| 2 |
|
San Martín de Tucumán | 16 | 9 | 5 | 2 | 22:13 | 9 | 32 |
| 3 |
|
Brown de Adrogué | 16 | 8 | 6 | 2 | 23:15 | 8 | 30 |
| 4 |
|
Instituto de Córdoba | 15 | 7 | 6 | 2 | 18:12 | 6 | 27 |
| 5 |
|
Estudiantes de Caseros | 16 | 7 | 6 | 3 | 16:11 | 5 | 27 |
| 6 |
|
Chacarita Juniors | 16 | 7 | 5 | 4 | 28:20 | 8 | 26 |
| 7 |
|
All Boys | 15 | 6 | 8 | 1 | 20:12 | 8 | 26 |
| 8 |
|
Gimnasia de Mendoza | 15 | 7 | 4 | 4 | 20:10 | 10 | 25 |
| 9 |
|
Almagro | 16 | 7 | 4 | 5 | 15:16 | -1 | 25 |
| 10 |
|
Chaco For Ever | 16 | 5 | 9 | 2 | 20:12 | 8 | 24 |
| 11 |
|
Deportivo Madryn | 16 | 6 | 6 | 4 | 23:17 | 6 | 24 |
| 12 |
|
Estudiantes de Río Cuarto | 16 | 6 | 6 | 4 | 15:16 | -1 | 24 |
| 13 |
|
Deportivo Maipú | 16 | 5 | 8 | 3 | 13:11 | 2 | 23 |
| 14 |
|
Guillermo Brown | 16 | 7 | 2 | 7 | 16:16 | 0 | 23 |
| 15 |
|
Agropecuario Argentino | 15 | 5 | 7 | 3 | 15:10 | 5 | 22 |
| 16 |
|
Quilmes | 15 | 5 | 7 | 3 | 20:16 | 4 | 22 |
| 17 |
|
San Martín de San Juan | 16 | 6 | 3 | 7 | 20:18 | 2 | 21 |
| 18 |
|
Independiente Rivadavia | 15 | 6 | 3 | 6 | 20:19 | 1 | 21 |
| 19 |
|
Deportivo Riestra | 15 | 4 | 8 | 3 | 11:12 | -1 | 20 |
| 20 |
|
Alvarado | 16 | 5 | 5 | 6 | 17:24 | -7 | 20 |
| 21 |
|
Almirante Brown | 15 | 4 | 7 | 4 | 18:18 | 0 | 19 |
|
Nueva Chicago | 16 | 4 | 7 | 5 | 18:18 | 0 | 19 | |
| 23 |
|
Defensores de Belgrano | 16 | 4 | 7 | 5 | 16:19 | -3 | 19 |
| 24 |
|
Deportivo Morón | 16 | 3 | 8 | 5 | 9:9 | 0 | 17 |
| 25 |
|
Atlanta | 16 | 3 | 8 | 5 | 15:17 | -2 | 17 |
| 26 |
|
Gimnasia de Jujuy | 16 | 4 | 5 | 7 | 14:23 | -9 | 17 |
| 27 |
|
Ferro Carril Oeste | 15 | 3 | 7 | 5 | 14:18 | -4 | 16 |
| 28 |
|
Temperley | 16 | 4 | 4 | 8 | 14:21 | -7 | 16 |
| 29 |
|
San Telmo | 15 | 3 | 6 | 6 | 15:24 | -9 | 15 |
| 30 |
|
Atlético Rafaela | 16 | 3 | 5 | 8 | 14:16 | -2 | 14 |
| 31 |
|
Mitre de SdE | 15 | 3 | 5 | 7 | 15:18 | -3 | 14 |
| 32 |
|
Sacachispas | 15 | 2 | 8 | 5 | 13:16 | -3 | 14 |
| 33 |
|
Villa Dálmine | 15 | 2 | 8 | 5 | 17:23 | -6 | 14 |
| 34 |
|
Güemes de SdE | 15 | 2 | 7 | 6 | 8:13 | -5 | 13 |
| 35 |
|
Flandria | 16 | 2 | 6 | 8 | 17:24 | -7 | 12 |
| 36 |
|
Tristan Suárez | 15 | 1 | 7 | 7 | 15:23 | -8 | 10 |
| 37 |
|
Ramón Santamarina | 16 | 1 | 6 | 9 | 10:26 | -16 | 9 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
