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| 02.07.2022 | 00:10 | Belgrano de Córdoba | - | Almagro | 2:1 (1:1) | |
| 19:10 | Deportivo Riestra | - | Nueva Chicago | 3:0 (1:0) | ||
| 20:00 | Almirante Brown | - | Estudiantes de Río Cuarto | 2:2 (2:2) | ||
| 23:05 | Estudiantes de Caseros | - | Agropecuario Argentino | 2:0 (1:0) | ||
| 03.07.2022 | 00:10 | All Boys | - | Quilmes | 3:1 (1:0) | |
| 01:10 | Chacarita Juniors | - | Brown de Adrogué | 2:1 (0:0) | ||
| 19:45 | Gimnasia de Mendoza | - | Independiente Rivadavia | 2:0 (1:0) | ||
| 20:00 | Guillermo Brown | - | Defensores de Belgrano | 0:3 (0:1) | ||
| 20:00 | San Telmo | - | Ferro Carril Oeste | 2:0 (0:0) | ||
| 20:30 | San Martín de San Juan | - | Sacachispas | 5:0 (2:0) | ||
| 20:30 | Flandria | - | Deportivo Morón | 0:0 (0:0) | ||
| 21:00 | Chaco For Ever | - | Mitre de SdE | 1:0 (0:0) | ||
| 21:00 | Güemes de SdE | - | Deportivo Maipú | 2:1 (0:1) | ||
| 21:00 | Ramón Santamarina | - | Tristan Suárez | 0:0 (0:0) | ||
| 22:00 | Atlanta | - | Instituto de Córdoba | 0:0 (0:0) | ||
| 23:30 | Atlético Rafaela | - | San Martín de Tucumán | 1:1 (1:0) | ||
| 04.07.2022 | 20:00 | Gimnasia de Jujuy | - | Deportivo Madryn | 0:0 (0:0) | |
| 20:00 | Villa Dálmine | - | Alvarado | 1:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 21 | 15 | 4 | 2 | 27:12 | 15 | 49 |
| 2 |
|
San Martín de Tucumán | 21 | 11 | 8 | 2 | 26:15 | 11 | 41 |
| 3 |
|
All Boys | 21 | 9 | 11 | 1 | 31:16 | 15 | 38 |
| 4 |
|
Instituto de Córdoba | 21 | 10 | 8 | 3 | 25:14 | 11 | 38 |
| 5 |
|
Gimnasia de Mendoza | 21 | 9 | 8 | 4 | 25:12 | 13 | 35 |
| 6 |
|
San Martín de San Juan | 22 | 10 | 5 | 7 | 31:21 | 10 | 35 |
| 7 |
|
Brown de Adrogué | 21 | 9 | 8 | 4 | 27:20 | 7 | 35 |
| 8 |
|
Estudiantes de Río Cuarto | 22 | 8 | 9 | 5 | 24:22 | 2 | 33 |
| 9 |
|
Independiente Rivadavia | 21 | 9 | 5 | 7 | 29:22 | 7 | 32 |
| 10 |
|
Almagro | 22 | 9 | 5 | 8 | 20:22 | -2 | 32 |
| 11 |
|
Deportivo Madryn | 22 | 7 | 10 | 5 | 29:22 | 7 | 31 |
| 12 |
|
Chacarita Juniors | 22 | 8 | 7 | 7 | 33:29 | 4 | 31 |
| 13 |
|
Deportivo Riestra | 21 | 7 | 10 | 4 | 19:15 | 4 | 31 |
| 14 |
|
Estudiantes de Caseros | 22 | 8 | 7 | 7 | 20:19 | 1 | 31 |
| 15 |
|
Guillermo Brown | 22 | 9 | 4 | 9 | 20:21 | -1 | 31 |
| 16 |
|
Chaco For Ever | 22 | 6 | 12 | 4 | 24:18 | 6 | 30 |
| 17 |
|
Defensores de Belgrano | 21 | 7 | 9 | 5 | 23:19 | 4 | 30 |
| 18 |
|
Deportivo Maipú | 22 | 6 | 12 | 4 | 22:19 | 3 | 30 |
| 19 |
|
Agropecuario Argentino | 21 | 5 | 11 | 5 | 21:19 | 2 | 26 |
| 20 |
|
Quilmes | 21 | 6 | 8 | 7 | 27:27 | 0 | 26 |
| 21 |
|
Gimnasia de Jujuy | 21 | 6 | 8 | 7 | 21:24 | -3 | 26 |
| 22 |
|
Ferro Carril Oeste | 21 | 6 | 8 | 7 | 18:22 | -4 | 26 |
| 23 |
|
Güemes de SdE | 21 | 6 | 7 | 8 | 17:18 | -1 | 25 |
| 24 |
|
Alvarado | 22 | 6 | 7 | 9 | 21:33 | -12 | 25 |
| 25 |
|
Deportivo Morón | 22 | 4 | 12 | 6 | 13:13 | 0 | 24 |
| 26 |
|
Nueva Chicago | 22 | 5 | 9 | 8 | 21:28 | -7 | 24 |
| 27 |
|
Mitre de SdE | 21 | 5 | 7 | 9 | 21:23 | -2 | 22 |
| 28 |
|
Atlanta | 22 | 4 | 10 | 8 | 18:22 | -4 | 22 |
| 29 |
|
Almirante Brown | 21 | 4 | 10 | 7 | 22:28 | -6 | 22 |
| 30 |
|
Temperley | 21 | 5 | 7 | 9 | 18:26 | -8 | 22 |
| 31 |
|
San Telmo | 21 | 5 | 7 | 9 | 22:35 | -13 | 22 |
| 32 |
|
Sacachispas | 21 | 3 | 12 | 6 | 17:24 | -7 | 21 |
| 33 |
|
Flandria | 21 | 4 | 8 | 9 | 21:27 | -6 | 20 |
| 34 |
|
Atlético Rafaela | 22 | 3 | 10 | 9 | 20:26 | -6 | 19 |
| 35 |
|
Tristan Suárez | 21 | 3 | 8 | 10 | 22:29 | -7 | 17 |
| 36 |
|
Villa Dálmine | 21 | 2 | 11 | 8 | 23:35 | -12 | 17 |
| 37 |
|
Ramón Santamarina | 22 | 2 | 8 | 12 | 14:35 | -21 | 14 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
