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| 03.12.2021 | 23:15 | Central Córdoba SdE | - | Unión de Santa Fe | 2:0 (1:0) | |
| 23:15 | Colón de Santa Fe | - | Atlético Tucumán | 3:0 (2:0) | ||
| 04.12.2021 | 01:30 | Vélez Sarsfield | - | Patronato de Paraná | 0:0 (0:0) | |
| 21:00 | Arsenal de Sarandí | - | Boca Juniors | 1:1 (0:1) | ||
| 23:15 | Sarmiento de Junín | - | Talleres de Córdoba | 1:2 (1:1) | ||
| 23:15 | Godoy Cruz | - | Platense | 2:2 (2:1) | ||
| 05.12.2021 | 01:30 | Huracán | - | Racing Club | 1:0 (1:0) | |
| 01:30 | Lanús | - | Rosario Central | 2:2 (1:0) | ||
| 21:00 | Gimnasia de La Plata | - | Estudiantes | 4:4 (3:2) | ||
| 23:15 | Independiente | - | San Lorenzo | 1:1 (0:0) | ||
| 06.12.2021 | 01:30 | River Plate | - | Defensa y Justicia | 2:3 (1:0) | |
| 23:15 | Aldosivi | - | Argentinos Juniors | 3:2 (2:2) | ||
| 07.12.2021 | 01:30 | Newell's Old Boys | - | Banfield | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 24 | 16 | 5 | 3 | 52:18 | 34 | 53 |
| 2 |
|
Talleres de Córdoba | 24 | 14 | 4 | 6 | 37:26 | 11 | 46 |
| 3 |
|
Defensa y Justicia | 24 | 12 | 8 | 4 | 41:23 | 18 | 44 |
| 4 |
|
Vélez Sarsfield | 24 | 10 | 9 | 5 | 32:18 | 14 | 39 |
| 5 |
|
Estudiantes | 24 | 10 | 9 | 5 | 41:28 | 13 | 39 |
| 6 |
|
Colón de Santa Fe | 24 | 11 | 6 | 7 | 26:28 | -2 | 39 |
| 7 |
|
Boca Juniors | 24 | 10 | 8 | 6 | 27:18 | 9 | 38 |
| 8 |
|
Lanús | 24 | 10 | 7 | 7 | 43:41 | 2 | 37 |
| 9 |
|
Independiente | 24 | 9 | 8 | 7 | 25:23 | 2 | 35 |
| 10 |
|
Huracán | 24 | 9 | 8 | 7 | 24:24 | 0 | 35 |
| 11 |
|
Gimnasia de La Plata | 24 | 9 | 8 | 7 | 27:28 | -1 | 35 |
| 12 |
|
Rosario Central | 24 | 9 | 5 | 10 | 38:37 | 1 | 32 |
| 13 |
|
Godoy Cruz | 24 | 8 | 7 | 9 | 34:31 | 3 | 31 |
| 14 |
|
Unión de Santa Fe | 24 | 9 | 4 | 11 | 29:32 | -3 | 31 |
| 15 |
|
Aldosivi | 24 | 9 | 3 | 12 | 26:37 | -11 | 30 |
| 16 |
|
Racing Club | 24 | 7 | 8 | 9 | 22:22 | 0 | 29 |
| 17 |
|
Argentinos Juniors | 24 | 7 | 8 | 9 | 24:25 | -1 | 29 |
| 18 |
|
Platense | 24 | 6 | 10 | 8 | 33:34 | -1 | 28 |
| 19 |
|
Newell's Old Boys | 24 | 7 | 7 | 10 | 22:29 | -7 | 28 |
| 20 |
|
Central Córdoba SdE | 24 | 6 | 8 | 10 | 29:28 | 1 | 26 |
| 21 |
|
Banfield | 24 | 5 | 11 | 8 | 20:25 | -5 | 26 |
| 22 |
|
Sarmiento de Junín | 24 | 6 | 6 | 12 | 23:31 | -8 | 24 |
| 23 |
|
San Lorenzo | 24 | 6 | 6 | 12 | 20:31 | -11 | 24 |
| 24 |
|
Patronato de Paraná | 24 | 5 | 9 | 10 | 23:35 | -12 | 24 |
| 25 |
|
Atlético Tucumán | 24 | 5 | 6 | 13 | 21:45 | -24 | 21 |
| 26 |
|
Arsenal de Sarandí | 24 | 4 | 8 | 12 | 12:34 | -22 | 20 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
