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| 27.08.2021 | 15:00 | Arsenal de Sarandí II | - | Defensa y Justicia II | 0:1 (0:0) | |
| 15:00 | Banfield II | - | Platense II | 1:3 (1:0) | ||
| 15:00 | Independiente II | - | Colón de Santa Fe II | 0:0 (0:0) | ||
| 19:00 | Boca Juniors II | - | Racing Club II | 4:0 (4:0) | ||
| 20:00 | Aldosivi II | - | Lanús II | 0:2 (0:2) | ||
| 30.08.2021 | 15:00 | San Lorenzo II | - | Patronato de Paraná II | 2:2 (1:1) | |
| 15:00 | Central Córdoba SdE II | - | Rosario Central II | 0:1 (0:0) | ||
| 15:00 | Gimnasia de La Plata II | - | Huracán II | 2:0 (0:0) | ||
| 15:00 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 (2:1) | ||
| 15:00 | Talleres de Córdoba II | - | Estudiantes II | 1:2 (1:1) | ||
| 15:00 | Unión de Santa Fe II | - | Argentinos Juniors II | 1:2 (1:0) | ||
| 31.08.2021 | 15:00 | Sarmiento de Junín II | - | River Plate II | 3:1 (2:1) | |
| 11.11.2021 | 18:00 | Vélez Sarsfield II | - | Godoy Cruz II | 3:0 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Colón de Santa Fe II | 9 | 6 | 2 | 1 | 10:4 | 6 | 20 |
| 2 |
|
Lanús II | 9 | 6 | 1 | 2 | 16:5 | 11 | 19 |
| 3 |
|
Gimnasia de La Plata II | 9 | 6 | 1 | 2 | 18:10 | 8 | 19 |
| 4 |
|
Estudiantes II | 9 | 5 | 4 | 0 | 18:12 | 6 | 19 |
| 5 |
|
Rosario Central II | 9 | 5 | 3 | 1 | 22:10 | 12 | 18 |
| 6 |
|
Argentinos Juniors II | 9 | 5 | 1 | 3 | 11:10 | 1 | 16 |
|
Platense II | 9 | 5 | 1 | 3 | 11:10 | 1 | 16 | |
| 8 |
|
River Plate II | 9 | 5 | 0 | 4 | 13:10 | 3 | 15 |
| 9 |
|
Banfield II | 9 | 4 | 3 | 2 | 14:12 | 2 | 15 |
| 10 |
|
Defensa y Justicia II | 9 | 4 | 3 | 2 | 10:12 | -2 | 15 |
| 11 |
|
Boca Juniors II | 9 | 4 | 2 | 3 | 19:9 | 10 | 14 |
| 12 |
|
Sarmiento de Junín II | 9 | 4 | 2 | 3 | 14:12 | 2 | 14 |
| 13 |
|
Atlético Tucumán II | 9 | 3 | 4 | 2 | 12:10 | 2 | 13 |
| 14 |
|
Patronato de Paraná II | 9 | 3 | 3 | 3 | 13:14 | -1 | 12 |
| 15 |
|
Talleres de Córdoba II | 9 | 3 | 3 | 3 | 10:12 | -2 | 12 |
| 16 |
|
Vélez Sarsfield II | 9 | 3 | 3 | 3 | 9:12 | -3 | 12 |
| 17 |
|
Newell's Old Boys II | 9 | 2 | 3 | 4 | 12:16 | -4 | 9 |
| 18 |
|
San Lorenzo II | 9 | 2 | 3 | 4 | 11:16 | -5 | 9 |
| 19 |
|
Godoy Cruz II | 9 | 2 | 3 | 4 | 10:15 | -5 | 9 |
| 20 |
|
Independiente II | 9 | 1 | 5 | 3 | 8:9 | -1 | 8 |
| 21 |
|
Arsenal de Sarandí II | 9 | 2 | 2 | 5 | 9:14 | -5 | 8 |
| 22 |
|
Unión de Santa Fe II | 9 | 2 | 2 | 5 | 7:13 | -6 | 8 |
| 23 |
|
Racing Club II | 9 | 1 | 4 | 4 | 8:14 | -6 | 7 |
| 24 |
|
Aldosivi II | 9 | 2 | 0 | 7 | 9:19 | -10 | 6 |
| 25 |
|
Huracán II | 9 | 1 | 2 | 6 | 6:12 | -6 | 5 |
| 26 |
|
Central Córdoba SdE II | 9 | 1 | 0 | 8 | 7:15 | -8 | 3 |
