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| H | Germinal Beerschot | - | KSV Roeselare | 5:1 | ||
| R | KSV Roeselare | - | Germinal Beerschot | 1:1 | ||
| H: 30.01.2008 20:30 | R: 27.02.2008 20:30 | Sieger: Germinal Beerschot | ||||
| H | KV Kortrijk | - | KAA Gent | 5:1 | ||
| R | KAA Gent | - | KV Kortrijk | 4:0 | ||
| H: 30.01.2008 20:30 | R: 27.02.2008 20:30 | Sieger: KAA Gent | ||||
| H | RSC Anderlecht | - | FCV Dender EH | 3:0 | ||
| R | FCV Dender EH | - | RSC Anderlecht | 1:1 | ||
| H: 30.01.2008 20:30 | R: 27.02.2008 20:30 | Sieger: RSC Anderlecht | ||||
| H | Cercle Brugge | - | Standard Liège | 4:1 | ||
| R | Standard Liège | - | Cercle Brugge | 4:0 | ||
| H: 30.01.2008 20:45 | R: 27.02.2008 20:45 | Sieger: Standard Liège | ||||
