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| 20.09.2011 | 20:30 | KV Kortrijk | - | Royal Antwerp FC | 6:5 (0:1, 1:1, 1:1) i.E. | |
| 20:30 | AFC Tubize | - | RAEC Mons | 0:3 (0:2) | ||
| 21.09.2011 | 20:00 | Standard Liège | - | Hoogstraten VV | 8:2 (5:2) | |
| 20:00 | SV Zulte Waregem | - | KSK Ronse | 6:0 (1:0) | ||
| 20:00 | Beerschot AC | - | Royal Mouscron-Péruwelz | 4:3 (0:1, 1:1, 1:1) i.E. | ||
| 20:30 | Sporting Lokeren | - | KAS Eupen | 3:0 (1:0) | ||
| 20:30 | KV Oostende | - | KV Mechelen | 0:3 (0:1) | ||
| 20:30 | KAA Gent | - | KSV Roeselare | 4:0 (2:0) | ||
| 20:30 | Sint-Truidense VV | - | Waasland-Beveren | 3:0 (2:0) | ||
| 20:30 | Oud-Heverlee Leuven | - | Rupel Boom FC | 1:2 (0:2) | ||
| 20:30 | KFC Dessel Sport | - | Club Brugge KV | 2:3 (2:0) | ||
| 20:30 | Lierse SK | - | KV Turnhout | 1:0 (0:0) | ||
| 20:30 | KVC Westerlo | - | Royal Géants Athois | 1:0 (0:0) | ||
| 20:30 | SK Deinze | - | KRC Genk | 2:6 (0:3) | ||
| 20:30 | Cercle Brugge | - | KRC Mechelen | 1:0 (0:0) | ||
| 20:45 | Lommel United | - | RSC Anderlecht | 0:4 (0:2) |
