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| H | KAA Gent | - | Club Brugge KV | 0:1 (0:0) | ||
| R | Club Brugge KV | - | KAA Gent | 0:3 (0:2) | ||
| H: 02.02.2022 20:45 | R: 02.03.2022 20:45 | Sieger: KAA Gent | ||||
| H | KAS Eupen | - | RSC Anderlecht | 2:2 (1:1) | ||
| R | RSC Anderlecht | - | KAS Eupen | 3:1 (2:1) | ||
| H: 03.02.2022 20:45 | R: 03.03.2022 20:45 | Sieger: RSC Anderlecht | ||||
