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| 03.12.2024 | 20:45 | Patro Eisden MM | - | Club Brugge KV | 1:3 (1:1) | |
| 04.12.2024 | 20:00 | Oud-Heverlee Leuven | - | SV Zulte Waregem | 5:0 (3:0) | |
| 20:00 | Union Saint-Gilloise | - | KAA Gent | 3:2 (1:1) | ||
| 20:30 | K Beerschot VA | - | KV Mechelen | 4:3 (0:0, 1:1, 2:2) i.E. | ||
| 20:30 | Cercle Brugge | - | Sint-Truidense VV | 0:1 (0:1) | ||
| 20:30 | KRC Genk | - | Standard Liège | 2:1 (0:0, 1:1) n.V. | ||
| 20:30 | KV Kortrijk | - | Royal Antwerp FC | 3:4 (0:0, 0:0, 0:0) i.E. | ||
| 05.12.2024 | 20:30 | RSC Anderlecht | - | KVC Westerlo | 4:1 (3:1) |
