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| H | Vila Nova - GO | - | Nova Mutum - MT | 3:0 (0:0) | ||
| R | Nova Mutum - MT | - | Vila Nova - GO | 1:1 (0:0) | ||
| H: 24.11.2021 23:30 | R: 02.12.2021 20:00 | Sieger: Vila Nova - GO | ||||
| H | Paysandu - PA | - | Remo - PA | 2:2 (2:0) | ||
| R | Remo - PA | - | Paysandu - PA | 2:0 (1:0) | ||
| H: 02.12.2021 00:00 | R: 04.12.2021 21:00 | Sieger: Remo - PA | ||||
