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| 16.11.2021 | 20:00 | Athletico Paranaense | - | Atlético Mineiro | 0:1 (0:1) | |
| 22:00 | Grêmio Porto Alegre | - | Red Bull Bragantino | 3:0 (3:0) | ||
| 17.11.2021 | 23:00 | América - MG | - | Atlético Goianiense | 0:0 (0:0) | |
| 23:00 | Cuiabá - MT | - | Internacional | 1:0 (0:0) | ||
| 23:00 | Santos FC | - | Chapecoense | 2:0 (1:0) | ||
| 18.11.2021 | 00:00 | Fortaleza | - | Ceará - CE | 0:4 (0:2) | |
| 00:30 | Juventude - RS | - | Fluminense RJ | 1:0 (1:0) | ||
| 00:30 | Palmeiras | - | São Paulo FC | 0:2 (0:1) | ||
| 01:30 | Flamengo RJ | - | Corinthians SP | 1:0 (0:0) | ||
| 19.11.2021 | 01:00 | Sport Recife - PE | - | Bahia - BA | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Mineiro | 33 | 23 | 5 | 5 | 54:24 | 30 | 74 |
| 2 |
|
Flamengo RJ | 33 | 19 | 7 | 7 | 64:30 | 34 | 64 |
| 3 |
|
Palmeiras | 33 | 18 | 4 | 11 | 52:39 | 13 | 58 |
| 4 |
|
Corinthians SP | 33 | 13 | 11 | 9 | 35:32 | 3 | 50 |
| 5 |
|
Fortaleza | 33 | 14 | 7 | 12 | 40:41 | -1 | 49 |
| 6 |
|
Red Bull Bragantino | 33 | 12 | 13 | 8 | 47:40 | 7 | 49 |
| 7 |
|
Internacional | 33 | 12 | 11 | 10 | 41:35 | 6 | 47 |
| 8 |
|
Fluminense RJ | 33 | 12 | 9 | 12 | 31:34 | -3 | 45 |
| 9 |
|
América - MG | 33 | 11 | 12 | 10 | 35:34 | 1 | 45 |
| 10 |
|
Ceará - CE | 33 | 10 | 15 | 8 | 35:33 | 2 | 45 |
| 11 |
|
Santos FC | 33 | 10 | 12 | 11 | 30:36 | -6 | 42 |
| 12 |
|
Cuiabá - MT | 33 | 9 | 15 | 9 | 31:32 | -1 | 42 |
| 13 |
|
Athletico Paranaense | 33 | 12 | 5 | 16 | 39:43 | -4 | 41 |
| 14 |
|
São Paulo FC | 33 | 9 | 14 | 10 | 26:33 | -7 | 41 |
| 15 |
|
Juventude - RS | 33 | 9 | 13 | 11 | 33:38 | -5 | 40 |
| 16 |
|
Atlético Goianiense | 33 | 9 | 13 | 11 | 25:33 | -8 | 40 |
| 17 |
|
Bahia - BA | 33 | 9 | 9 | 15 | 35:46 | -11 | 36 |
| 18 |
|
Grêmio Porto Alegre | 33 | 9 | 6 | 18 | 32:43 | -11 | 33 |
| 19 |
|
Sport Recife - PE | 33 | 8 | 9 | 16 | 21:30 | -9 | 33 |
| 20 |
|
Chapecoense | 33 | 1 | 12 | 20 | 26:56 | -30 | 15 |
| Copa Libertadores | |
| Qualifikation | |
| Copa Sudamericana | |
| Abstieg |
