 |
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| H | Marathón | - | Portland Timbers | -:- | ||
| R | Portland Timbers | - | Marathón | -:- | ||
| H: 07.04.2021 00:00 | R: 14.04.2021 02:00 | |||||
| H | LD Alajuelense | - | Atlanta United FC | -:- | ||
| R | Atlanta United FC | - | LD Alajuelense | -:- | ||
| H: 07.04.2021 02:00 | R: 14.04.2021 00:00 | |||||
| H | Arcahaie FC | - | Cruz Azul | -:- | ||
| R | Cruz Azul | - | Arcahaie FC | -:- | ||
| H: 07.04.2021 04:00 | R: 14.04.2021 04:00 | |||||
| H | Deportivo Saprissa | - | Philadelphia Union | -:- | ||
| R | Philadelphia Union | - | Deportivo Saprissa | -:- | ||
| H: 08.04.2021 00:00 | R: 15.04.2021 02:00 | |||||
| H | Club León | - | Forge / Toronto | -:- | ||
| R | Forge / Toronto | - | Club León | -:- | ||
| H: 08.04.2021 02:00 | R: 15.04.2021 00:00 | |||||
| H | Olimpia | - | CF América | -:- | ||
| R | CF América | - | Olimpia | -:- | ||
| H: 08.04.2021 04:00 | R: 15.04.2021 02:00 | |||||
| H | Real Estelí | - | Columbus Crew | -:- | ||
| R | Columbus Crew | - | Real Estelí | -:- | ||
| H: 09.04.2021 02:00 | R: 16.04.2021 02:00 | |||||
| H | CD Pantoja | - | CF Monterrey | -:- | ||
| R | CF Monterrey | - | CD Pantoja | -:- | ||
| H: 09.04.2021 04:00 | R: 16.04.2021 04:00 | |||||
