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| H | AEK Larnaca | - | Ethnikos Achna | 1:2 (1:1) | ||
| R | Ethnikos Achna | - | AEK Larnaca | 3:1 (0:1) | ||
| H: 26.04.2022 17:00 | R: 04.05.2022 18:00 | Sieger: Ethnikos Achna | ||||
| H | Anorthosis Famagusta | - | Omonia Nikosia | 0:2 (0:2) | ||
| R | Omonia Nikosia | - | Anorthosis Famagusta | 1:1 (1:1) | ||
| H: 26.04.2022 18:00 | R: 04.05.2022 18:00 | Sieger: Omonia Nikosia | ||||
