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| 06.03.2021 | 14:00 | 1. FK Příbram | - | Slovan Liberec | 0:2 (0:0) | |
| 16:00 | FC Fastav Zlín | - | Bohemians Praha 1905 | 0:0 (0:0) | ||
| 16:00 | FK Teplice | - | SFC Opava | 3:1 (1:1) | ||
| 18:30 | Viktoria Plzeň | - | Sigma Olomouc | 1:0 (0:0) | ||
| 07.03.2021 | 14:00 | Dynamo České Budějovice | - | FK Mladá Boleslav | 1:3 (0:1) | |
| 14:00 | MFK Karviná | - | Zbrojovka Brno | 1:1 (1:0) | ||
| 18:30 | Slavia Praha | - | Baník Ostrava | 2:1 (2:0) | ||
| 13.04.2021 | 14:30 | FK Pardubice | - | 1. FC Slovácko | 3:1 (2:1) | |
| 14.04.2021 | 18:00 | FK Jablonec | - | AC Sparta Praha | 1:0 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praha | 22 | 18 | 4 | 0 | 63:15 | 48 | 58 |
| 2 |
|
AC Sparta Praha | 22 | 15 | 2 | 5 | 47:25 | 22 | 47 |
| 3 |
|
FK Jablonec | 22 | 13 | 3 | 6 | 37:25 | 12 | 42 |
| 4 |
|
1. FC Slovácko | 22 | 12 | 4 | 6 | 42:24 | 18 | 40 |
| 5 |
|
Slovan Liberec | 22 | 11 | 6 | 5 | 34:19 | 15 | 39 |
| 6 |
|
Viktoria Plzeň | 22 | 11 | 4 | 7 | 39:26 | 13 | 37 |
| 7 |
|
FK Pardubice | 22 | 10 | 4 | 8 | 24:29 | -5 | 34 |
| 8 |
|
Sigma Olomouc | 22 | 7 | 9 | 6 | 29:25 | 4 | 30 |
| 9 |
|
Baník Ostrava | 22 | 8 | 6 | 8 | 27:23 | 4 | 30 |
| 10 |
|
Dynamo České Budějovice | 22 | 7 | 9 | 6 | 26:28 | -2 | 30 |
| 11 |
|
FC Fastav Zlín | 22 | 7 | 5 | 10 | 21:29 | -8 | 26 |
| 12 |
|
MFK Karviná | 22 | 6 | 8 | 8 | 25:34 | -9 | 26 |
| 13 |
|
Bohemians Praha 1905 | 22 | 6 | 7 | 9 | 23:27 | -4 | 25 |
| 14 |
|
FK Teplice | 22 | 6 | 4 | 12 | 23:43 | -20 | 22 |
| 15 |
|
FK Mladá Boleslav | 22 | 4 | 7 | 11 | 27:37 | -10 | 19 |
| 16 |
|
Zbrojovka Brno | 22 | 3 | 6 | 13 | 17:36 | -19 | 15 |
| 17 |
|
SFC Opava | 22 | 2 | 6 | 14 | 14:43 | -29 | 12 |
| 18 |
|
1. FK Příbram | 22 | 2 | 6 | 14 | 16:46 | -30 | 12 |
| Champions League Quali. | |
| Europa League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
