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| 19.11.2010 | 18:15 | Bohemians 1905 | - | Viktoria Plzeň | 1:0 (1:0) | |
| 20.11.2010 | 16:00 | Slovan Liberec | - | FK Ústí nad Labem | 3:0 (1:0) | |
| 18:20 | FK Mladá Boleslav | - | Slavia Praha | 3:1 (1:0) | ||
| 21.11.2010 | 15:00 | FC Hradec Králové | - | 1. FC Slovácko | 0:0 (0:0) | |
| 15:00 | Sigma Olomouc | - | 1. FK Příbram | 3:1 (3:1) | ||
| 16:00 | AC Sparta Praha | - | Dynamo České Budějovice | 2:0 (1:0) | ||
| 22.11.2010 | 17:00 | Zbrojovka Brno | - | Baník Ostrava | 0:2 (0:0) | |
| 18:00 | FK Teplice | - | FK Baumit Jablonec | 1:2 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Viktoria Plzeň | 17 | 13 | 2 | 2 | 43:16 | 27 | 41 |
| 2 |
|
AC Sparta Praha | 17 | 12 | 1 | 4 | 29:11 | 18 | 37 |
| 3 |
|
Sigma Olomouc | 17 | 9 | 4 | 4 | 34:14 | 20 | 31 |
| 4 |
|
FK Baumit Jablonec | 17 | 9 | 3 | 5 | 31:19 | 12 | 30 |
| 5 |
|
FK Mladá Boleslav | 17 | 8 | 6 | 3 | 31:21 | 10 | 30 |
| 6 |
|
FK Teplice | 17 | 7 | 4 | 6 | 22:23 | -1 | 25 |
| 7 |
|
Slovan Liberec | 17 | 6 | 5 | 6 | 24:21 | 3 | 23 |
| 8 |
|
Bohemians 1905 | 17 | 6 | 4 | 7 | 19:20 | -1 | 22 |
| 9 |
|
1. FC Slovácko | 17 | 6 | 2 | 9 | 17:27 | -10 | 20 |
| 10 |
|
Baník Ostrava | 17 | 5 | 4 | 8 | 19:23 | -4 | 19 |
| 11 |
|
FC Hradec Králové | 17 | 4 | 6 | 7 | 12:19 | -7 | 18 |
| 12 |
|
Dynamo České Budějovice | 17 | 4 | 6 | 7 | 13:28 | -15 | 18 |
| 13 |
|
1. FK Příbram | 17 | 4 | 6 | 7 | 11:19 | -8 | 18 |
| 14 |
|
Slavia Praha | 17 | 3 | 7 | 7 | 18:25 | -7 | 16 |
| 15 |
|
Zbrojovka Brno | 17 | 5 | 0 | 12 | 22:35 | -13 | 15 |
| 16 |
|
FK Ústí nad Labem | 17 | 2 | 6 | 9 | 13:37 | -24 | 12 |
| Champions League Quali. | |
| Europa League | |
| Abstieg |
