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| H | LDU Quito | - | Barcelona | 2:0 (1:0) | ||
| R | Barcelona | - | LDU Quito | 0:1 (0:0) | ||
| H: 07.08.2021 17:30 | R: 14.08.2021 20:00 | Sieger: LDU Quito | ||||
| H | Espuce FC | - | Deportivo Cuenca | 0:1 (0:0) | ||
| R | Deportivo Cuenca | - | Espuce FC | 1:0 (0:0) | ||
| H: 07.08.2021 20:00 | R: 15.08.2021 17:30 | Sieger: Deportivo Cuenca | ||||
| H | UPS Carneras | - | Dragonas IDV | 0:1 (0:0) | ||
| R | Dragonas IDV | - | UPS Carneras | 3:0 (1:0) | ||
| H: 08.08.2021 17:30 | R: 15.08.2021 17:30 | Sieger: Dragonas IDV | ||||
| H | Macará | - | Ñañas | 2:4 (1:2) | ||
| R | Ñañas | - | Macará | 5:1 (0:1) | ||
| H: 08.08.2021 20:00 | R: 14.08.2021 17:30 | Sieger: Ñañas | ||||
