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| 23.08.2021 | 19:00 | Ismaily | - | Tala'ea El Gaish SC | 0:0 (0:0) | |
| 21:00 | Al Masry Club | - | ENPPI | 1:3 (0:1) | ||
| 24.08.2021 | 17:30 | Wadi Degla SC | - | Ceramica Cleopatra | 0:0 (0:0) | |
| 17:30 | Ittihad El Iskandary | - | National Bank SC | 0:0 (0:0) | ||
| 21:00 | Zamalek | - | El Entag El Harby | 2:0 (1:0) | ||
| 21:00 | El Gouna | - | Al Ahly SC | 3:3 (1:0) | ||
| 21:30 | Aswan SC | - | Smouha Sporting Club | 1:3 (0:2) | ||
| 25.08.2021 | 19:00 | Ghazl Al Mehalla | - | Al Mokawloon | 1:2 (1:0) | |
| 21:00 | Misr lel-Maqasah SC | - | Pyramids FC | 0:5 (0:4) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zamalek | 33 | 24 | 7 | 2 | 60:20 | 40 | 79 |
| 2 |
|
Al Ahly SC | 33 | 21 | 10 | 2 | 70:28 | 42 | 73 |
| 3 |
|
Smouha Sporting Club | 33 | 12 | 17 | 4 | 54:41 | 13 | 53 |
| 4 |
|
Pyramids FC | 33 | 12 | 16 | 5 | 51:37 | 14 | 52 |
| 5 |
|
Al Masry Club | 33 | 13 | 10 | 10 | 44:38 | 6 | 49 |
| 6 |
|
ENPPI | 33 | 11 | 13 | 9 | 37:35 | 2 | 46 |
| 7 |
|
Ittihad El Iskandary | 33 | 11 | 12 | 10 | 35:35 | 0 | 45 |
| 8 |
|
Tala'ea El Gaish SC | 33 | 10 | 11 | 12 | 41:37 | 4 | 41 |
| 9 |
|
Al Mokawloon | 33 | 11 | 8 | 14 | 37:45 | -8 | 41 |
| 10 |
|
Ceramica Cleopatra | 33 | 8 | 15 | 10 | 39:43 | -4 | 39 |
| 11 |
|
El Gouna | 33 | 8 | 14 | 11 | 36:41 | -5 | 38 |
| 12 |
|
Misr lel-Maqasah SC | 33 | 10 | 7 | 16 | 36:54 | -18 | 37 |
| 13 |
|
Ismaily | 33 | 9 | 11 | 13 | 39:42 | -3 | 35 |
| 14 |
|
Ghazl Al Mehalla | 33 | 7 | 14 | 12 | 28:41 | -13 | 35 |
| 15 |
|
National Bank SC | 33 | 6 | 16 | 11 | 38:43 | -5 | 34 |
| 16 |
|
Wadi Degla SC | 33 | 5 | 14 | 14 | 29:38 | -9 | 29 |
| 17 |
|
El Entag El Harby | 33 | 5 | 12 | 16 | 35:60 | -25 | 27 |
| 18 |
|
Aswan SC | 33 | 6 | 9 | 18 | 28:59 | -31 | 27 |
| Champions League | |
| Confederation Cup | |
| Abstieg |
|
# Ismaily wurden 3 Punkte abgezogen. |
