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| H | Tranmere Rovers | - | Port Vale FC | 2:0 | ||
| R | Port Vale FC | - | Tranmere Rovers | 1:2 | ||
| H: 05.10.1981 | R: 28.10.1981 | Sieger: Tranmere Rovers | ||||
| H | Aldershot FC | - | Wigan Athletic | 2:2 | ||
| R | Wigan Athletic | - | Aldershot FC | 1:0 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Wigan Athletic | ||||
| H | Barnsley FC | - | Swansea City | 2:0 | ||
| R | Swansea City | - | Barnsley FC | 3:2 n.V. | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Barnsley FC | ||||
| H | Birmingham City | - | Nottingham Forest | 2:3 | ||
| R | Nottingham Forest | - | Birmingham City | 2:1 | ||
| H: 06.10.1981 | R: 28.10.1981 | Sieger: Nottingham Forest | ||||
| H | Bristol Rovers | - | Northampton Town | 1:2 | ||
| R | Northampton Town | - | Bristol Rovers | 3:1 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Northampton Town | ||||
| H | Carlisle United | - | Bristol City | 0:0 | ||
| R | Bristol City | - | Carlisle United | 2:1 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Bristol City | ||||
| H | Colchester United | - | Cambridge United | 3:1 | ||
| R | Cambridge United | - | Colchester United | 3:2 n.V. | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Colchester United | ||||
| H | Doncaster Rovers | - | Crystal Palace | 1:0 | ||
| R | Crystal Palace | - | Doncaster Rovers | 2:0 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Crystal Palace | ||||
| H | Everton FC | - | Coventry City | 1:1 | ||
| R | Coventry City | - | Everton FC | 0:1 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Everton FC | ||||
| H | Grimsby Town | - | Watford FC | 1:0 | ||
| R | Watford FC | - | Grimsby Town | 3:1 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Watford FC | ||||
| H | Huddersfield Town | - | Brighton & Hove Albion | 1:0 | ||
| R | Brighton & Hove Albion | - | Huddersfield Town | 2:0 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Brighton & Hove Albion | ||||
| H | Luton Town | - | Wrexham AFC | 0:2 | ||
| R | Wrexham AFC | - | Luton Town | 0:1 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Wrexham AFC | ||||
| H | Middlesbrough FC | - | Plymouth Argyle | 2:1 | ||
| R | Plymouth Argyle | - | Middlesbrough FC | 0:0 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Middlesbrough FC | ||||
| H | Millwall FC | - | Oxford United | 3:3 | ||
| R | Oxford United | - | Millwall FC | 1:0 | ||
| H: 06.10.1981 | R: 28.10.1981 | Sieger: Oxford United | ||||
| H | Oldham Athletic | - | Newport County | 1:0 | ||
| R | Newport County | - | Oldham Athletic | 0:0 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Oldham Athletic | ||||
| H | Preston North End | - | Leicester City | 1:0 | ||
| R | Leicester City | - | Preston North End | 4:0 | ||
| H: 06.10.1981 | R: 28.10.1981 | Sieger: Leicester City | ||||
| H | Queens Park Rangers | - | Portsmouth FC | 5:0 | ||
| R | Portsmouth FC | - | Queens Park Rangers | 2:2 | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Queens Park Rangers | ||||
| H | Sheffield United | - | Arsenal FC | 1:0 | ||
| R | Arsenal FC | - | Sheffield United | 2:0 n.V. | ||
| H: 06.10.1981 | R: 27.10.1981 | Sieger: Arsenal FC | ||||
| H | Shrewsbury Town | - | West Bromwich Albion | 3:3 | ||
| R | West Bromwich Albion | - | Shrewsbury Town | 2:1 | ||
| H: 06.10.1981 | R: 28.10.1981 | Sieger: West Bromwich Albion | ||||
| H | Southampton FC | - | Chelsea FC | 1:1 | ||
| R | Chelsea FC | - | Southampton FC | 2:1 n.V. | ||
| H: 06.10.1981 | R: 28.10.1981 | Sieger: Chelsea FC | ||||
| H | Aston Villa | - | Wolverhampton Wanderers | 3:2 | ||
| R | Wolverhampton Wanderers | - | Aston Villa | 1:2 | ||
| H: 07.10.1981 | R: 27.10.1981 | Sieger: Aston Villa | ||||
| H | Blackburn Rovers | - | Sheffield Wednesday | 1:1 | ||
| R | Sheffield Wednesday | - | Blackburn Rovers | 1:2 | ||
| H: 07.10.1981 | R: 27.10.1981 | Sieger: Blackburn Rovers | ||||
| H | Bradford City | - | Mansfield Town | 3:4 | ||
| R | Mansfield Town | - | Bradford City | 0:2 | ||
| H: 07.10.1981 | R: 26.10.1981 | Sieger: Bradford City | ||||
| H | Derby County | - | West Ham United | 2:3 | ||
| R | West Ham United | - | Derby County | 2:0 | ||
| H: 07.10.1981 | R: 27.10.1981 | Sieger: West Ham United | ||||
| H | Leeds United | - | Ipswich Town | 0:1 | ||
| R | Ipswich Town | - | Leeds United | 3:0 | ||
| H: 07.10.1981 | R: 27.10.1981 | Sieger: Ipswich Town | ||||
| H | Lincoln City | - | Notts County | 1:1 | ||
| R | Notts County | - | Lincoln City | 2:3 | ||
| H: 07.10.1981 | R: 27.10.1981 | Sieger: Lincoln City | ||||
| H | Liverpool FC | - | Exeter City | 5:0 | ||
| R | Exeter City | - | Liverpool FC | 0:6 | ||
| H: 07.10.1981 | R: 28.10.1981 | Sieger: Liverpool FC | ||||
| H | Manchester City | - | Stoke City | 2:0 | ||
| R | Stoke City | - | Manchester City | 8:9 i.E. | ||
| H: 07.10.1981 | R: 28.10.1981 | Sieger: Manchester City | ||||
| H | Newcastle United | - | Fulham FC | 1:2 | ||
| R | Fulham FC | - | Newcastle United | 2:0 | ||
| H: 07.10.1981 | R: 27.10.1981 | Sieger: Fulham FC | ||||
| H | Norwich City | - | Charlton Athletic | 1:0 | ||
| R | Charlton Athletic | - | Norwich City | 0:1 | ||
| H: 07.10.1981 | R: 28.10.1981 | Sieger: Norwich City | ||||
| H | Sunderland AFC | - | Rotherham United | 2:0 | ||
| R | Rotherham United | - | Sunderland AFC | 3:3 | ||
| H: 07.10.1981 | R: 27.10.1981 | Sieger: Sunderland AFC | ||||
| H | Tottenham Hotspur | - | Manchester United | 1:0 | ||
| R | Manchester United | - | Tottenham Hotspur | 0:1 | ||
| H: 07.10.1981 | R: 28.10.1981 | Sieger: Tottenham Hotspur | ||||
