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| 02.04.2022 | 13:00 | Liverpool FC U23 | - | Chelsea FC U23 | 2:2 (2:0) | |
| 04.04.2022 | 20:00 | Arsenal FC U23 | - | Manchester City U23 | 3:3 (1:1) | |
| 20:00 | Brighton & Hove Albion U23 | - | Derby County U23 | 5:1 (3:1) | ||
| 20:00 | Everton FC U23 | - | Blackburn Rovers U23 | 0:2 (0:1) | ||
| 20:00 | Leeds United U23 | - | Crystal Palace U23 | 4:0 (1:0) | ||
| 20:00 | Leicester City U23 | - | Manchester United U23 | 3:2 (3:0) | ||
| 20:00 | West Ham United U23 | - | Tottenham Hotspur U23 | 3:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Manchester City U23 | 24 | 14 | 6 | 4 | 55:31 | 24 | 48 |
| 2 |
|
West Ham United U23 | 24 | 13 | 3 | 8 | 50:36 | 14 | 42 |
| 3 |
|
Arsenal FC U23 | 24 | 10 | 9 | 5 | 54:46 | 8 | 39 |
| 4 |
|
Manchester United U23 | 24 | 11 | 5 | 8 | 44:39 | 5 | 38 |
| 5 |
|
Leicester City U23 | 24 | 10 | 7 | 7 | 36:46 | -10 | 37 |
| 6 |
|
Crystal Palace U23 | 24 | 11 | 3 | 10 | 50:46 | 4 | 36 |
| 7 |
|
Liverpool FC U23 | 24 | 9 | 7 | 8 | 40:36 | 4 | 34 |
| 8 |
|
Tottenham Hotspur U23 | 24 | 9 | 6 | 9 | 48:45 | 3 | 33 |
| 9 |
|
Brighton & Hove Albion U23 | 24 | 9 | 6 | 9 | 40:39 | 1 | 33 |
| 10 |
|
Blackburn Rovers U23 | 24 | 7 | 8 | 9 | 44:52 | -8 | 29 |
| 11 |
|
Everton FC U23 | 24 | 8 | 5 | 11 | 30:43 | -13 | 29 |
| 12 |
|
Leeds United U23 | 24 | 7 | 5 | 12 | 42:45 | -3 | 26 |
| 13 |
|
Chelsea FC U23 | 24 | 6 | 7 | 11 | 34:42 | -8 | 25 |
| 14 |
|
Derby County U23 | 24 | 4 | 3 | 17 | 31:52 | -21 | 15 |
| Abstieg |
