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| 22.04.2022 | 20:00 | Manchester United U23 | - | Arsenal FC U23 | 1:1 (0:1) | |
| 20:00 | Leeds United U23 | - | Manchester City U23 | 1:3 (1:2) | ||
| 25.04.2022 | 20:00 | Blackburn Rovers U23 | - | Crystal Palace U23 | 2:1 (2:0) | |
| 20:00 | Brighton & Hove Albion U23 | - | Chelsea FC U23 | 1:2 (0:1) | ||
| 20:00 | Derby County U23 | - | Tottenham Hotspur U23 | 0:1 (0:1) | ||
| 20:00 | Everton FC U23 | - | West Ham United U23 | 3:4 (2:1) | ||
| 20:00 | Leicester City U23 | - | Liverpool FC U23 | 0:4 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Manchester City U23 | 25 | 15 | 6 | 4 | 58:32 | 26 | 51 |
| 2 |
|
West Ham United U23 | 25 | 14 | 3 | 8 | 54:39 | 15 | 45 |
| 3 |
|
Arsenal FC U23 | 25 | 10 | 10 | 5 | 55:47 | 8 | 40 |
| 4 |
|
Manchester United U23 | 25 | 11 | 6 | 8 | 45:40 | 5 | 39 |
| 5 |
|
Liverpool FC U23 | 25 | 10 | 7 | 8 | 44:36 | 8 | 37 |
| 6 |
|
Leicester City U23 | 25 | 10 | 7 | 8 | 36:50 | -14 | 37 |
| 7 |
|
Tottenham Hotspur U23 | 25 | 10 | 6 | 9 | 49:45 | 4 | 36 |
| 8 |
|
Crystal Palace U23 | 25 | 11 | 3 | 11 | 51:48 | 3 | 36 |
| 9 |
|
Brighton & Hove Albion U23 | 25 | 9 | 6 | 10 | 41:41 | 0 | 33 |
| 10 |
|
Blackburn Rovers U23 | 25 | 8 | 8 | 9 | 46:53 | -7 | 32 |
| 11 |
|
Everton FC U23 | 25 | 8 | 5 | 12 | 33:47 | -14 | 29 |
| 12 |
|
Chelsea FC U23 | 25 | 7 | 7 | 11 | 36:43 | -7 | 28 |
| 13 |
|
Leeds United U23 | 25 | 7 | 5 | 13 | 43:48 | -5 | 26 |
| 14 |
|
Derby County U23 | 25 | 4 | 3 | 18 | 31:53 | -22 | 15 |
| Abstieg |
