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| H | Valencia CF | - | Sevilla FC | 3:2 (1:0) | ||
| R | Sevilla FC | - | Valencia CF | 2:1 (1:1) | ||
| H: 21.01.2009 21:00 | R: 29.01.2009 20:00 | Sieger: Sevilla FC | ||||
| H | Espanyol Barcelona | - | FC Barcelona | 0:0 (0:0) | ||
| R | FC Barcelona | - | Espanyol Barcelona | 3:2 (1:0) | ||
| H: 21.01.2009 22:00 | R: 29.01.2009 21:30 | Sieger: FC Barcelona | ||||
| H | Athletic Bilbao | - | Sporting Gijón | 0:0 (0:0) | ||
| R | Sporting Gijón | - | Athletic Bilbao | 1:2 (1:1) | ||
| H: 22.01.2009 20:00 | R: 28.01.2009 21:00 | Sieger: Athletic Bilbao | ||||
| H | RCD Mallorca | - | Real Betis | 1:0 (0:0) | ||
| R | Real Betis | - | RCD Mallorca | 0:0 (0:0) | ||
| H: 22.01.2009 21:00 | R: 28.01.2009 21:00 | Sieger: RCD Mallorca | ||||
