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| 05.05.2018 | 18:00 | UCAM Murcia CF | - | Marbella FC | 2:1 (1:0) | |
| 21:00 | CF Villanovense | - | Córdoba CF B | 0:1 (0:0) | ||
| 06.05.2018 | 11:30 | Real Betis B | - | CD Badajoz | 3:1 (1:1) | |
| 12:00 | UD Melilla | - | San Fernando CD | 2:0 (1:0) | ||
| 12:00 | Recreativo Huelva | - | UD Las Palmas B | 1:1 (1:0) | ||
| 17:30 | Lorca Deportiva | - | Real Murcia | 0:2 (0:1) | ||
| 18:00 | Mérida AD | - | Extremadura UD | 0:2 (0:0) | ||
| 18:00 | CD El Ejido 2012 | - | Granada CF B | 0:2 (0:1) | ||
| 18:30 | Écija Balompié | - | FC Jumilla | 0:2 (0:0) | ||
| 18:30 | RB Linense | - | FC Cartagena | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Cartagena | 37 | 20 | 10 | 7 | 51:33 | 18 | 70 |
| 2 |
|
Marbella FC | 37 | 19 | 10 | 8 | 48:27 | 21 | 67 |
| 3 |
|
Real Murcia | 37 | 18 | 11 | 8 | 49:31 | 18 | 65 |
| 4 |
|
Extremadura UD | 37 | 16 | 9 | 12 | 54:38 | 16 | 57 |
| 5 |
|
UD Melilla | 37 | 16 | 9 | 12 | 41:24 | 17 | 57 |
| 6 |
|
CF Villanovense | 37 | 14 | 12 | 11 | 29:32 | -3 | 54 |
| 7 |
|
Granada CF B | 37 | 13 | 12 | 12 | 34:33 | 1 | 51 |
| 8 |
|
UCAM Murcia CF | 37 | 13 | 12 | 12 | 37:41 | -4 | 51 |
| 9 |
|
San Fernando CD | 37 | 12 | 12 | 13 | 46:45 | 1 | 48 |
| 10 |
|
CD El Ejido 2012 | 37 | 12 | 12 | 13 | 53:54 | -1 | 48 |
| 11 |
|
Recreativo Huelva | 37 | 12 | 11 | 14 | 33:35 | -2 | 47 |
| 12 |
|
UD Las Palmas B | 37 | 12 | 10 | 15 | 44:43 | 1 | 46 |
| 13 |
|
RB Linense | 37 | 10 | 15 | 12 | 42:37 | 5 | 45 |
| 14 |
|
CD Badajoz | 37 | 11 | 12 | 14 | 45:44 | 1 | 45 |
| 15 |
|
Écija Balompié | 37 | 11 | 11 | 15 | 38:56 | -18 | 44 |
| 16 |
|
FC Jumilla | 37 | 10 | 14 | 13 | 29:42 | -13 | 44 |
| 17 |
|
Mérida AD | 37 | 10 | 13 | 14 | 32:41 | -9 | 43 |
| 18 |
|
Córdoba CF B | 37 | 11 | 10 | 16 | 39:49 | -10 | 43 |
| 19 |
|
Real Betis B | 37 | 9 | 13 | 15 | 47:56 | -9 | 40 |
| 20 |
|
Lorca Deportiva | 37 | 8 | 8 | 21 | 33:63 | -30 | 32 |
| Playoffs | |
| Playoffs | |
| Relegation | |
| Abstieg |
