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| 18.03.2022 | 21:00 | SD Huesca | - | Burgos CF | 1:0 (1:0) | |
| 19.03.2022 | 14:00 | Real Sociedad B | - | CD Mirandés | 1:3 (1:0) | |
| 16:00 | FC Cartagena | - | Real Zaragoza | 3:0 (1:0) | ||
| 16:00 | CF Fuenlabrada | - | Málaga CF | 1:0 (0:0) | ||
| 18:15 | CD Lugo | - | Real Oviedo | 1:1 (0:0) | ||
| 18:15 | Real Valladolid | - | UD Las Palmas | 0:1 (0:0) | ||
| 21:00 | Girona FC | - | UD Ibiza | 5:1 (3:0) | ||
| 20.03.2022 | 14:00 | SD Amorebieta | - | AD Alcorcón | 0:0 (0:0) | |
| 16:00 | SD Ponferradina | - | SD Eibar | 2:2 (2:0) | ||
| 18:15 | CD Leganés | - | Sporting Gijón | 1:1 (0:1) | ||
| 21.03.2022 | 21:00 | CD Tenerife | - | UD Almería | 0:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SD Eibar | 32 | 18 | 9 | 5 | 47:34 | 13 | 63 |
| 2 |
|
UD Almería | 32 | 19 | 5 | 8 | 51:28 | 23 | 62 |
| 3 |
|
Real Valladolid | 32 | 17 | 7 | 8 | 50:34 | 16 | 58 |
| 4 |
|
CD Tenerife | 32 | 16 | 7 | 9 | 43:27 | 16 | 55 |
| 5 |
|
Girona FC | 32 | 15 | 7 | 10 | 49:35 | 14 | 52 |
| 6 |
|
SD Ponferradina | 32 | 13 | 12 | 7 | 42:35 | 7 | 51 |
| 7 |
|
FC Cartagena | 32 | 14 | 4 | 14 | 45:43 | 2 | 46 |
| 8 |
|
Real Oviedo | 32 | 10 | 15 | 7 | 38:32 | 6 | 45 |
| 9 |
|
UD Las Palmas | 32 | 11 | 11 | 10 | 39:39 | 0 | 44 |
| 10 |
|
UD Ibiza | 32 | 10 | 13 | 9 | 41:41 | 0 | 43 |
| 11 |
|
CD Lugo | 32 | 8 | 18 | 6 | 40:37 | 3 | 42 |
| 12 |
|
CD Leganés | 32 | 10 | 12 | 10 | 36:35 | 1 | 42 |
| 13 |
|
Real Zaragoza | 32 | 9 | 15 | 8 | 29:34 | -5 | 42 |
| 14 |
|
Burgos CF | 32 | 12 | 6 | 14 | 34:31 | 3 | 42 |
| 15 |
|
SD Huesca | 32 | 10 | 11 | 11 | 37:31 | 6 | 41 |
| 16 |
|
CD Mirandés | 32 | 11 | 6 | 15 | 42:50 | -8 | 39 |
| 17 |
|
Málaga CF | 32 | 9 | 10 | 13 | 27:45 | -18 | 37 |
| 18 |
|
Sporting Gijón | 32 | 9 | 9 | 14 | 35:40 | -5 | 36 |
| 19 |
|
Real Sociedad B | 32 | 7 | 9 | 16 | 29:41 | -12 | 30 |
| 20 |
|
CF Fuenlabrada | 32 | 5 | 14 | 13 | 26:40 | -14 | 29 |
| 21 |
|
SD Amorebieta | 32 | 4 | 15 | 13 | 34:49 | -15 | 27 |
| 22 |
|
AD Alcorcón | 32 | 3 | 9 | 20 | 24:57 | -33 | 18 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
