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| 25.03.2022 | 21:00 | Real Zaragoza | - | SD Amorebieta | 1:1 (0:0) | |
| 26.03.2022 | 14:00 | UD Ibiza | - | Real Sociedad B | 2:2 (1:1) | |
| 16:00 | SD Eibar | - | CD Lugo | 1:0 (0:0) | ||
| 18:00 | Sporting Gijón | - | FC Cartagena | 4:1 (1:1) | ||
| 21:30 | Real Oviedo | - | CF Fuenlabrada | 3:0 (1:0) | ||
| 27.03.2022 | 14:00 | CD Mirandés | - | SD Ponferradina | 3:1 (2:0) | |
| 16:00 | Burgos CF | - | CD Tenerife | 1:0 (0:0) | ||
| 18:15 | AD Alcorcón | - | Real Valladolid | 1:2 (1:2) | ||
| 18:15 | Málaga CF | - | SD Huesca | 0:2 (0:0) | ||
| 21:00 | UD Almería | - | Girona FC | 0:1 (0:1) | ||
| 28.03.2022 | 21:00 | UD Las Palmas | - | CD Leganés | 4:2 (3:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SD Eibar | 33 | 19 | 9 | 5 | 48:34 | 14 | 66 |
| 2 |
|
UD Almería | 33 | 19 | 5 | 9 | 51:29 | 22 | 62 |
| 3 |
|
Real Valladolid | 33 | 18 | 7 | 8 | 52:35 | 17 | 61 |
| 4 |
|
CD Tenerife | 33 | 16 | 7 | 10 | 43:28 | 15 | 55 |
| 5 |
|
Girona FC | 33 | 16 | 7 | 10 | 50:35 | 15 | 55 |
| 6 |
|
SD Ponferradina | 33 | 13 | 12 | 8 | 43:38 | 5 | 51 |
| 7 |
|
Real Oviedo | 33 | 11 | 15 | 7 | 41:32 | 9 | 48 |
| 8 |
|
UD Las Palmas | 33 | 12 | 11 | 10 | 43:41 | 2 | 47 |
| 9 |
|
FC Cartagena | 33 | 14 | 4 | 15 | 46:47 | -1 | 46 |
| 10 |
|
Burgos CF | 33 | 13 | 6 | 14 | 35:31 | 4 | 45 |
| 11 |
|
UD Ibiza | 33 | 10 | 14 | 9 | 43:43 | 0 | 44 |
| 12 |
|
SD Huesca | 33 | 11 | 11 | 11 | 39:31 | 8 | 44 |
| 13 |
|
Real Zaragoza | 33 | 9 | 16 | 8 | 30:35 | -5 | 43 |
| 14 |
|
CD Lugo | 33 | 8 | 18 | 7 | 40:38 | 2 | 42 |
| 15 |
|
CD Leganés | 33 | 10 | 12 | 11 | 38:39 | -1 | 42 |
| 16 |
|
CD Mirandés | 33 | 12 | 6 | 15 | 45:51 | -6 | 42 |
| 17 |
|
Sporting Gijón | 33 | 10 | 9 | 14 | 39:41 | -2 | 39 |
| 18 |
|
Málaga CF | 33 | 9 | 10 | 14 | 27:47 | -20 | 37 |
| 19 |
|
Real Sociedad B | 33 | 7 | 10 | 16 | 31:43 | -12 | 31 |
| 20 |
|
CF Fuenlabrada | 33 | 5 | 14 | 14 | 26:43 | -17 | 29 |
| 21 |
|
SD Amorebieta | 33 | 4 | 16 | 13 | 35:50 | -15 | 28 |
| 22 |
|
AD Alcorcón | 33 | 3 | 9 | 21 | 25:59 | -34 | 18 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
