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| 01.04.2022 | 21:00 | Girona FC | - | Málaga CF | 1:0 (0:0) | |
| 02.04.2022 | 16:00 | Real Sociedad B | - | AD Alcorcón | 2:4 (2:2) | |
| 16:00 | Real Valladolid | - | CD Lugo | 4:1 (1:0) | ||
| 18:15 | SD Amorebieta | - | UD Ibiza | 3:1 (0:0) | ||
| 20:30 | CD Tenerife | - | Real Zaragoza | 1:1 (1:1) | ||
| 03.04.2022 | 14:00 | FC Cartagena | - | Real Oviedo | 1:2 (1:1) | |
| 16:00 | Burgos CF | - | Sporting Gijón | 0:0 (0:0) | ||
| 16:00 | SD Ponferradina | - | UD Las Palmas | 1:2 (1:0) | ||
| 18:15 | SD Eibar | - | CD Mirandés | 1:1 (0:0) | ||
| 18:15 | SD Huesca | - | UD Almería | 1:1 (1:1) | ||
| 04.04.2022 | 21:00 | CD Leganés | - | CF Fuenlabrada | 3:2 (1:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SD Eibar | 34 | 19 | 10 | 5 | 49:35 | 14 | 67 |
| 2 |
|
Real Valladolid | 34 | 19 | 7 | 8 | 56:36 | 20 | 64 |
| 3 |
|
UD Almería | 34 | 19 | 6 | 9 | 52:30 | 22 | 63 |
| 4 |
|
Girona FC | 34 | 17 | 7 | 10 | 51:35 | 16 | 58 |
| 5 |
|
CD Tenerife | 34 | 16 | 8 | 10 | 44:29 | 15 | 56 |
| 6 |
|
SD Ponferradina | 34 | 13 | 12 | 9 | 44:40 | 4 | 51 |
| 7 |
|
Real Oviedo | 34 | 12 | 15 | 7 | 43:33 | 10 | 51 |
| 8 |
|
UD Las Palmas | 34 | 13 | 11 | 10 | 45:42 | 3 | 50 |
| 9 |
|
FC Cartagena | 34 | 14 | 4 | 16 | 47:49 | -2 | 46 |
| 10 |
|
Burgos CF | 34 | 13 | 7 | 14 | 35:31 | 4 | 46 |
| 11 |
|
CD Leganés | 34 | 11 | 12 | 11 | 41:41 | 0 | 45 |
| 12 |
|
SD Huesca | 34 | 11 | 12 | 11 | 40:32 | 8 | 45 |
| 13 |
|
UD Ibiza | 34 | 10 | 14 | 10 | 44:46 | -2 | 44 |
| 14 |
|
Real Zaragoza | 34 | 9 | 17 | 8 | 31:36 | -5 | 44 |
| 15 |
|
CD Mirandés | 34 | 12 | 7 | 15 | 46:52 | -6 | 43 |
| 16 |
|
CD Lugo | 34 | 8 | 18 | 8 | 41:42 | -1 | 42 |
| 17 |
|
Sporting Gijón | 34 | 10 | 10 | 14 | 39:41 | -2 | 40 |
| 18 |
|
Málaga CF | 34 | 9 | 10 | 15 | 27:48 | -21 | 37 |
| 19 |
|
SD Amorebieta | 34 | 5 | 16 | 13 | 38:51 | -13 | 31 |
| 20 |
|
Real Sociedad B | 34 | 7 | 10 | 17 | 33:47 | -14 | 31 |
| 21 |
|
CF Fuenlabrada | 34 | 5 | 14 | 15 | 28:46 | -18 | 29 |
| 22 |
|
AD Alcorcón | 34 | 4 | 9 | 21 | 29:61 | -32 | 21 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
