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| 15.04.2022 | 18:30 | SD Eibar | - | UD Las Palmas | 2:2 (1:2) | |
| 21:00 | SD Amorebieta | - | CD Mirandés | 1:0 (0:0) | ||
| 16.04.2022 | 16:00 | CD Leganés | - | Málaga CF | 0:3 (0:0) | |
| 18:15 | Real Valladolid | - | UD Almería | 2:2 (1:1) | ||
| 20:30 | Sporting Gijón | - | Real Oviedo | 0:1 (0:0) | ||
| 21:00 | FC Cartagena | - | AD Alcorcón | 3:1 (1:1) | ||
| 17.04.2022 | 14:00 | SD Ponferradina | - | CD Lugo | 3:1 (1:0) | |
| 16:00 | Burgos CF | - | UD Ibiza | 2:1 (1:0) | ||
| 18:15 | CD Tenerife | - | CF Fuenlabrada | 3:1 (2:0) | ||
| 18:15 | SD Huesca | - | Real Zaragoza | 1:1 (1:1) | ||
| 18.04.2022 | 19:00 | Girona FC | - | Real Sociedad B | 2:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SD Eibar | 36 | 19 | 11 | 6 | 51:39 | 12 | 68 |
| 2 |
|
UD Almería | 36 | 20 | 7 | 9 | 57:32 | 25 | 67 |
| 3 |
|
Real Valladolid | 36 | 19 | 9 | 8 | 60:40 | 20 | 66 |
| 4 |
|
CD Tenerife | 36 | 18 | 8 | 10 | 49:31 | 18 | 62 |
| 5 |
|
Girona FC | 36 | 18 | 7 | 11 | 53:36 | 17 | 61 |
| 6 |
|
Real Oviedo | 36 | 14 | 15 | 7 | 45:33 | 12 | 57 |
| 7 |
|
UD Las Palmas | 36 | 14 | 12 | 10 | 48:44 | 4 | 54 |
| 8 |
|
SD Ponferradina | 36 | 14 | 12 | 10 | 47:44 | 3 | 54 |
| 9 |
|
FC Cartagena | 36 | 15 | 4 | 17 | 50:51 | -1 | 49 |
| 10 |
|
Burgos CF | 36 | 14 | 7 | 15 | 38:35 | 3 | 49 |
| 11 |
|
SD Huesca | 36 | 12 | 13 | 11 | 44:35 | 9 | 49 |
| 12 |
|
Real Zaragoza | 36 | 10 | 18 | 8 | 33:37 | -4 | 48 |
| 13 |
|
UD Ibiza | 36 | 11 | 14 | 11 | 47:48 | -1 | 47 |
| 14 |
|
CD Mirandés | 36 | 13 | 7 | 16 | 49:54 | -5 | 46 |
| 15 |
|
CD Lugo | 36 | 9 | 18 | 9 | 43:45 | -2 | 45 |
| 16 |
|
CD Leganés | 36 | 11 | 12 | 13 | 41:45 | -4 | 45 |
| 17 |
|
Sporting Gijón | 36 | 10 | 11 | 15 | 40:43 | -3 | 41 |
| 18 |
|
Málaga CF | 36 | 10 | 11 | 15 | 32:50 | -18 | 41 |
| 19 |
|
SD Amorebieta | 36 | 6 | 16 | 14 | 39:52 | -13 | 34 |
| 20 |
|
Real Sociedad B | 36 | 7 | 10 | 19 | 34:51 | -17 | 31 |
| 21 |
|
CF Fuenlabrada | 36 | 5 | 14 | 17 | 31:52 | -21 | 29 |
| 22 |
|
AD Alcorcón | 36 | 4 | 10 | 22 | 31:65 | -34 | 22 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
