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| 06.05.2022 | 21:00 | UD Las Palmas | - | CD Mirandés | 1:0 (1:0) | |
| 07.05.2022 | 16:00 | CF Fuenlabrada | - | Real Sociedad B | 1:2 (1:0) | |
| 16:00 | SD Huesca | - | Sporting Gijón | 1:1 (0:0) | ||
| 18:15 | Málaga CF | - | Real Oviedo | 0:0 (0:0) | ||
| 18:15 | UD Almería | - | SD Amorebieta | 3:0 (0:0) | ||
| 21:00 | SD Ponferradina | - | Burgos CF | 3:1 (2:0) | ||
| 08.05.2022 | 14:00 | FC Cartagena | - | CD Leganés | 0:0 (0:0) | |
| 16:00 | SD Eibar | - | Real Valladolid | 0:2 (0:0) | ||
| 18:15 | UD Ibiza | - | CD Lugo | 1:1 (0:1) | ||
| 18:15 | Real Zaragoza | - | AD Alcorcón | 0:3 (0:1) | ||
| 09.05.2022 | 21:00 | Girona FC | - | CD Tenerife | 0:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 39 | 23 | 7 | 9 | 63:32 | 31 | 76 |
| 2 |
|
SD Eibar | 39 | 21 | 11 | 7 | 56:42 | 14 | 74 |
| 3 |
|
Real Valladolid | 39 | 21 | 9 | 9 | 64:42 | 22 | 72 |
| 4 |
|
CD Tenerife | 39 | 20 | 9 | 10 | 52:31 | 21 | 69 |
| 5 |
|
Girona FC | 39 | 19 | 7 | 13 | 54:40 | 14 | 64 |
| 6 |
|
Real Oviedo | 39 | 16 | 16 | 7 | 50:34 | 16 | 64 |
| 7 |
|
SD Ponferradina | 39 | 17 | 12 | 10 | 57:49 | 8 | 63 |
| 8 |
|
UD Las Palmas | 39 | 16 | 13 | 10 | 52:46 | 6 | 61 |
| 9 |
|
FC Cartagena | 39 | 16 | 5 | 18 | 55:55 | 0 | 53 |
| 10 |
|
UD Ibiza | 39 | 12 | 16 | 11 | 50:50 | 0 | 52 |
| 11 |
|
SD Huesca | 39 | 12 | 15 | 12 | 46:38 | 8 | 51 |
| 12 |
|
CD Leganés | 39 | 12 | 14 | 13 | 43:46 | -3 | 50 |
| 13 |
|
Burgos CF | 39 | 14 | 8 | 17 | 39:40 | -1 | 50 |
| 14 |
|
Real Zaragoza | 39 | 10 | 19 | 10 | 33:42 | -9 | 49 |
| 15 |
|
CD Lugo | 39 | 9 | 20 | 10 | 44:48 | -4 | 47 |
| 16 |
|
CD Mirandés | 39 | 13 | 7 | 19 | 49:59 | -10 | 46 |
| 17 |
|
Sporting Gijón | 39 | 10 | 12 | 17 | 41:46 | -5 | 42 |
| 18 |
|
Málaga CF | 39 | 10 | 12 | 17 | 34:55 | -21 | 42 |
| 19 |
|
Real Sociedad B | 39 | 10 | 10 | 19 | 40:54 | -14 | 40 |
| 20 |
|
SD Amorebieta | 39 | 7 | 16 | 16 | 42:58 | -16 | 37 |
| 21 |
|
CF Fuenlabrada | 39 | 5 | 14 | 20 | 35:59 | -24 | 29 |
| 22 |
|
AD Alcorcón | 39 | 5 | 10 | 24 | 35:68 | -33 | 25 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
