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| 16.10.2021 | 15:00 | Toulouse FC | - | AJ Auxerre | 6:0 (3:0) | |
| 19:00 | AS Nancy Lorraine | - | EA Guingamp | 2:1 (0:1) | ||
| 19:00 | Dijon FCO | - | Amiens SC | 1:0 (0:0) | ||
| 19:00 | Pau FC | - | Paris FC | 1:0 (1:0) | ||
| 19:00 | Valenciennes FC | - | USL Dunkerque | 1:3 (0:2) | ||
| 19:00 | Rodez AF | - | FC Sochaux | 0:1 (0:0) | ||
| 19:00 | SC Bastia | - | Grenoble Foot 38 | 0:0 (0:0) | ||
| 19:00 | SM Caen | - | Havre AC | 2:2 (1:1) | ||
| 19:00 | US Quevilly-Rouen | - | Chamois Niortais | 0:3 (0:2) | ||
| 18.10.2021 | 20:45 | Nîmes Olympique | - | AC Ajaccio | 0:2 (0:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Toulouse FC | 12 | 8 | 3 | 1 | 28:9 | 19 | 27 |
| 2 |
|
FC Sochaux | 12 | 8 | 2 | 2 | 13:6 | 7 | 26 |
| 3 |
|
AC Ajaccio | 12 | 6 | 4 | 2 | 14:7 | 7 | 22 |
| 4 |
|
Havre AC | 12 | 5 | 6 | 1 | 13:7 | 6 | 21 |
| 5 |
|
AJ Auxerre | 12 | 5 | 5 | 2 | 18:13 | 5 | 20 |
| 6 |
|
Chamois Niortais | 12 | 5 | 3 | 4 | 13:10 | 3 | 18 |
| 7 |
|
Pau FC | 12 | 5 | 3 | 4 | 13:11 | 2 | 18 |
| 8 |
|
Paris FC | 12 | 5 | 2 | 5 | 14:13 | 1 | 17 |
| 9 |
|
SM Caen | 12 | 4 | 3 | 5 | 15:14 | 1 | 15 |
| 10 |
|
US Quevilly-Rouen | 12 | 4 | 3 | 5 | 12:15 | -3 | 15 |
| 11 |
|
Grenoble Foot 38 | 12 | 4 | 3 | 5 | 12:16 | -4 | 15 |
| 12 |
|
Valenciennes FC | 12 | 4 | 3 | 5 | 11:17 | -6 | 15 |
| 13 |
|
Nîmes Olympique | 12 | 3 | 5 | 4 | 14:14 | 0 | 14 |
| 14 |
|
EA Guingamp | 12 | 3 | 5 | 4 | 11:14 | -3 | 14 |
| 15 |
|
Rodez AF | 12 | 3 | 4 | 5 | 11:15 | -4 | 13 |
| 16 |
|
Dijon FCO | 12 | 4 | 1 | 7 | 12:18 | -6 | 13 |
| 17 |
|
USL Dunkerque | 12 | 3 | 3 | 6 | 12:16 | -4 | 12 |
| 18 |
|
SC Bastia | 12 | 2 | 5 | 5 | 9:13 | -4 | 11 |
| 19 |
|
Amiens SC | 12 | 1 | 6 | 5 | 11:16 | -5 | 9 |
| 20 |
|
AS Nancy Lorraine | 12 | 1 | 5 | 6 | 9:21 | -12 | 8 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
