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| 07.02.2022 | 16:00 | Zenit St. Petersburg | - | AIK Solna | n.gesp. | |
| 08.02.2022 | 13:00 | Rapid Wien (A) | - | Sileks Kratovo | 0:1 (0:1) | |
| 16:00 | Brentford FC U23 | - | Brøndby IF | 1:0 (1:0) | ||
| 20:30 | Vålerenga IF | - | Halmstads BK | 1:2 (0:1) | ||
| 09.02.2022 | 12:00 | Lyngby BK | - | CSKA Moskva | 2:3 (1:2) | |
| 10.02.2022 | 09:00 | Dinamo Kiev | - | Široki Brijeg | 4:1 (2:0) | |
| 15:00 | FC Dornbirn | - | Austria Lustenau | 3:1 (1:1) | ||
| 16:00 | FC København | - | Zenit St. Petersburg | 2:3 (0:1, 1:1) i.E. | ||
| 16:00 | IFK Göteborg | - | Lokomotiv Moskva | 2:4 (2:1) | ||
| 11.02.2022 | 12:00 | Halmstads BK | - | Brentford FC U23 | 2:1 (2:1) | |
| 14:00 | FC Juniors OÖ | - | FC Liefering | 2:0 (0:0) | ||
| 14:00 | Brøndby IF | - | Zenit St. Petersburg | 1:2 (0:0) | ||
| 17:00 | Breiðablik | - | FC København | 3:4 (2:0) | ||
| 19:30 | FC Dornbirn | - | FC Balzers | n.gesp. | ||
| 19:30 | FC Midtjylland | - | Vålerenga IF | 3:1 (1:1) | ||
| 12.02.2022 | 13:30 | SV Heimstetten | - | SSV Ulm 1846 | 1:3 (1:2) | |
| 15:00 | Odense BK | - | Zorya Lugansk | 2:3 (1:1) | ||
| 15:00 | Djurgårdens IF | - | Lillestrøm SK | 1:0 (1:0) | ||
| 15:00 | Holstein Kiel II | - | Niendorfer TSV | 5:0 | ||
| 13.02.2022 | 13:00 | Vejle BK | - | FC Fredericia | 3:3 (2:2) |
