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| 04.12.2021 | 13:45 | Olympiakos Volou | - | Pierikos Katerini | 0:1 (0:1) | |
| 13:45 | Apollon Lárissa | - | AEP Iraklis FC | 0:1 (0:0) | ||
| 05.12.2021 | 13:45 | Almopos Arideas | - | Thesprotos | 1:0 (1:0) | |
| 13:45 | Niki Volou FC | - | Xanthi FC | 0:1 (0:0) | ||
| 13:45 | PAOK Saloniki II | - | Anagennisi Karditsa | 2:1 (1:1) | ||
| 13:45 | AO Trikala | - | Apollon Pontou | 2:0 (0:0) | ||
| 13:45 | AE Lárissa | - | Veria FC | 1:1 (0:0) | ||
| 13:45 | Olympiakos Piraeus II | - | Panserraikos | 2:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 6 | 4 | 2 | 0 | 10:4 | 6 | 14 |
| 2 |
|
Xanthi FC | 5 | 4 | 1 | 0 | 11:1 | 10 | 13 |
| 3 |
|
Olympiakos Piraeus II | 5 | 3 | 2 | 0 | 8:4 | 4 | 11 |
| 4 |
|
Anagennisi Karditsa | 6 | 3 | 0 | 3 | 11:6 | 5 | 9 |
| 5 |
|
Niki Volou FC | 6 | 2 | 3 | 1 | 6:3 | 3 | 9 |
| 6 |
|
Almopos Arideas | 6 | 3 | 0 | 3 | 6:8 | -2 | 9 |
| 7 |
|
AE Lárissa | 5 | 2 | 2 | 1 | 6:3 | 3 | 8 |
| 8 |
|
PAOK Saloniki II | 6 | 2 | 2 | 2 | 8:7 | 1 | 8 |
| 9 |
|
AEP Iraklis FC | 6 | 1 | 5 | 0 | 3:2 | 1 | 8 |
| 10 |
|
Pierikos Katerini | 6 | 2 | 1 | 3 | 10:8 | 2 | 7 |
| 11 |
|
AO Trikala | 6 | 1 | 4 | 1 | 6:5 | 1 | 7 |
| 12 |
|
Thesprotos | 5 | 2 | 0 | 3 | 8:3 | 5 | 6 |
| 13 |
|
Panserraikos | 6 | 1 | 3 | 2 | 6:8 | -2 | 6 |
| 14 |
|
Olympiakos Volou | 6 | 1 | 2 | 3 | 6:13 | -7 | 5 |
| 15 |
|
Apollon Pontou | 6 | 1 | 1 | 4 | 9:10 | -1 | 4 |
| 16 |
|
AO Kavala | 5 | 1 | 0 | 4 | 3:28 | -25 | 3 |
| 17 |
|
Apollon Lárissa | 5 | 0 | 2 | 3 | 5:9 | -4 | 2 |
| Playoffs | |
| Abstieg |
|
# Apollon Lárissa wurde mit einem Abzug von 6 Punkten belegt. |
