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| 11.12.2021 | 13:45 | Veria FC | - | Apollon Lárissa | 5:1 (2:0) | |
| 13:45 | Pierikos Katerini | - | PAOK Saloniki II | 0:0 (0:0) | ||
| 13:45 | Xanthi FC | - | Olympiakos Volou | 2:0 (1:0) | ||
| 13:45 | Thesprotos | - | Niki Volou FC | 2:0 (2:0) | ||
| 13:45 | AO Kavala | - | Almopos Arideas | 0:6 (0:4) | ||
| 12.12.2021 | 13:45 | AEP Iraklis FC | - | Olympiakos Piraeus II | 0:0 (0:0) | |
| 13:45 | Apollon Pontou | - | AE Lárissa | 1:3 (1:3) | ||
| 13:45 | Anagennisi Karditsa | - | AO Trikala | 4:2 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 7 | 5 | 2 | 0 | 15:5 | 10 | 17 |
| 2 |
|
Xanthi FC | 6 | 5 | 1 | 0 | 13:1 | 12 | 16 |
| 3 |
|
Anagennisi Karditsa | 7 | 4 | 0 | 3 | 15:8 | 7 | 12 |
| 4 |
|
Almopos Arideas | 7 | 4 | 0 | 3 | 12:8 | 4 | 12 |
| 5 |
|
Olympiakos Piraeus II | 6 | 3 | 3 | 0 | 8:4 | 4 | 12 |
| 6 |
|
AE Lárissa | 6 | 3 | 2 | 1 | 9:4 | 5 | 11 |
| 7 |
|
Thesprotos | 6 | 3 | 0 | 3 | 10:3 | 7 | 9 |
| 8 |
|
PAOK Saloniki II | 7 | 2 | 3 | 2 | 8:7 | 1 | 9 |
| 9 |
|
Niki Volou FC | 7 | 2 | 3 | 2 | 6:5 | 1 | 9 |
| 10 |
|
AEP Iraklis FC | 7 | 1 | 6 | 0 | 3:2 | 1 | 9 |
| 11 |
|
Pierikos Katerini | 7 | 2 | 2 | 3 | 10:8 | 2 | 8 |
| 12 |
|
AO Trikala | 7 | 1 | 4 | 2 | 8:9 | -1 | 7 |
| 13 |
|
Panserraikos | 6 | 1 | 3 | 2 | 6:8 | -2 | 6 |
| 14 |
|
Olympiakos Volou | 7 | 1 | 2 | 4 | 6:15 | -9 | 5 |
| 15 |
|
Apollon Pontou | 7 | 1 | 1 | 5 | 10:13 | -3 | 4 |
| 16 |
|
AO Kavala | 6 | 1 | 0 | 5 | 3:34 | -31 | 3 |
| 17 |
|
Apollon Lárissa | 6 | 0 | 2 | 4 | 6:14 | -8 | 2 |
| Playoffs | |
| Abstieg |
|
# Apollon Lárissa wurde mit einem Abzug von 6 Punkten belegt. |
