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| 01.05.2022 | 16:00 | Olympiakos Piraeus | - | PAS Giannina | 3:2 (2:1) | |
| 18:00 | Panathinaikos | - | Aris Saloniki | 1:0 (1:0) | ||
| 20:00 | PAOK Saloniki | - | AEK Athen | 1:1 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Olympiakos Piraeus | 32 | 23 | 7 | 2 | 56:21 | 35 | 76 |
| 2 |
|
PAOK Saloniki | 32 | 18 | 6 | 8 | 55:30 | 25 | 60 |
| 3 |
|
Panathinaikos | 32 | 16 | 6 | 10 | 46:23 | 23 | 54 |
| 4 |
|
Aris Saloniki | 32 | 15 | 8 | 9 | 32:25 | 7 | 53 |
| 5 |
|
AEK Athen | 32 | 15 | 7 | 10 | 49:36 | 13 | 52 |
| 6 |
|
PAS Giannina | 32 | 11 | 10 | 11 | 33:32 | 1 | 43 |
| Champions League Quali. | |
| Europa Conference League Quali. |
