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| H | Antigua GFC | - | Comunicaciones | 0:0 (0:0) | ||
| R | Comunicaciones | - | Antigua GFC | 0:3 (0:2) | ||
| H: 31.12.2020 17:00 | R: 18.01.2021 01:00 | Sieger: Antigua GFC | ||||
| H | Xelaju MC | - | Deportivo Malacateco | 1:0 (1:0) | ||
| R | Deportivo Malacateco | - | Xelaju MC | 0:2 (0:1) | ||
| H: 31.12.2020 17:00 | R: 03.01.2021 19:00 | Sieger: Xelaju MC | ||||
| H | Deportivo Guastatoya | - | Cobán Imperial | 0:0 (0:0) | ||
| R | Cobán Imperial | - | Deportivo Guastatoya | 1:2 (0:0) | ||
| H: 31.12.2020 18:00 | R: 03.01.2021 19:00 | Sieger: Deportivo Guastatoya | ||||
| H | Iztapa | - | CSD Municipal | 1:3 (0:1) | ||
| R | CSD Municipal | - | Iztapa | 3:1 (2:0) | ||
| H: 31.12.2020 19:00 | R: 03.01.2021 18:00 | Sieger: CSD Municipal | ||||
