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| 04.01.2021 | 15:00 | Cosenza Calcio | - | Empoli FC | 0:2 (0:1) | |
| 15:00 | Venezia FC | - | AC Pisa | 1:1 (0:1) | ||
| 16:00 | US Lecce | - | AC Monza | 0:0 (0:0) | ||
| 17:00 | Ascoli Calcio | - | Reggina 1914 | 2:1 (0:1) | ||
| 18:00 | Frosinone Calcio | - | SPAL 2013 Ferrara | 1:2 (1:1) | ||
| 18:00 | AC Reggiana 1919 | - | Delfino Pescara | 0:1 (0:0) | ||
| 18:00 | US Cremonese | - | Chievo Verona | 0:2 (0:1) | ||
| 18:00 | US Salernitana 1919 | - | Pordenone Calcio | 0:2 (0:0) | ||
| 18:00 | Virtus Entella | - | AS Cittadella | 1:0 (1:0) | ||
| 21:00 | Brescia Calcio | - | Vicenza Virtus | 0:3 (0:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Empoli FC | 17 | 9 | 7 | 1 | 29:14 | 15 | 34 |
| 2 |
|
US Salernitana 1919 | 17 | 9 | 4 | 4 | 22:18 | 4 | 31 |
| 3 |
|
AS Cittadella | 17 | 9 | 3 | 5 | 30:16 | 14 | 30 |
| 4 |
|
AC Monza | 17 | 8 | 6 | 3 | 25:12 | 13 | 30 |
| 5 |
|
SPAL 2013 Ferrara | 17 | 8 | 5 | 4 | 23:16 | 7 | 29 |
| 6 |
|
Chievo Verona | 17 | 7 | 7 | 3 | 23:15 | 8 | 28 |
| 7 |
|
US Lecce | 17 | 6 | 8 | 3 | 31:22 | 9 | 26 |
| 8 |
|
Frosinone Calcio | 17 | 7 | 5 | 5 | 17:16 | 1 | 26 |
| 9 |
|
Venezia FC | 17 | 6 | 7 | 4 | 21:16 | 5 | 25 |
| 10 |
|
Pordenone Calcio | 17 | 5 | 9 | 3 | 20:15 | 5 | 24 |
| 11 |
|
Brescia Calcio | 17 | 5 | 6 | 6 | 26:28 | -2 | 21 |
| 12 |
|
AC Pisa | 17 | 4 | 9 | 4 | 23:29 | -6 | 21 |
| 13 |
|
Vicenza Virtus | 17 | 4 | 8 | 5 | 24:25 | -1 | 20 |
| 14 |
|
Reggina 1914 | 17 | 4 | 5 | 8 | 16:24 | -8 | 17 |
| 15 |
|
Delfino Pescara | 17 | 4 | 4 | 9 | 15:28 | -13 | 16 |
| 16 |
|
Cosenza Calcio | 17 | 2 | 9 | 6 | 11:14 | -3 | 15 |
| 17 |
|
AC Reggiana 1919 | 17 | 4 | 3 | 10 | 15:29 | -14 | 15 |
| 18 |
|
US Cremonese | 17 | 3 | 6 | 8 | 15:23 | -8 | 15 |
| 19 |
|
Virtus Entella | 17 | 3 | 5 | 9 | 14:29 | -15 | 14 |
| 20 |
|
Ascoli Calcio | 17 | 3 | 4 | 10 | 15:26 | -11 | 13 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
