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| 08.01.2023 | 14:30 | Afragolese | - | US Bitonto | 1:2 (1:1) | |
| 14:30 | ASG Nocerina | - | FBC Gravina | 2:1 (1:1) | ||
| 14:30 | Casarano | - | Martina | 1:0 (1:0) | ||
| 14:30 | Lavello | - | Città di Fasano | 0:2 (0:1) | ||
| 14:30 | Matera Calcio | - | Sporting Fulgor Molfetta | 1:0 (1:0) | ||
| 14:30 | Puteolana Internapoli | - | ACD Nardò | 1:2 (1:2) | ||
| 15:00 | Team Altamura | - | Cavese | 1:1 (1:0) | ||
| 15:00 | Brindisi | - | FC Francavilla | 0:0 (0:0) | ||
| 15:30 | SS Barletta Calcio | - | Gladiator | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cavese | 18 | 11 | 4 | 3 | 33:19 | 14 | 37 |
| 2 |
|
SS Barletta Calcio | 18 | 10 | 5 | 3 | 20:13 | 7 | 35 |
| 3 |
|
Brindisi | 18 | 9 | 5 | 4 | 30:18 | 12 | 32 |
| 4 |
|
Team Altamura | 18 | 8 | 8 | 2 | 28:16 | 12 | 32 |
| 5 |
|
ACD Nardò | 18 | 8 | 8 | 2 | 20:12 | 8 | 32 |
| 6 |
|
Casarano | 18 | 7 | 9 | 2 | 26:19 | 7 | 30 |
| 7 |
|
Città di Fasano | 18 | 8 | 5 | 5 | 27:18 | 9 | 29 |
| 8 |
|
Matera Calcio | 18 | 7 | 6 | 5 | 28:28 | 0 | 27 |
| 9 |
|
US Bitonto | 18 | 7 | 4 | 7 | 23:22 | 1 | 25 |
| 10 |
|
ASG Nocerina | 18 | 6 | 6 | 6 | 23:24 | -1 | 24 |
| 11 |
|
Gladiator | 18 | 5 | 7 | 6 | 26:28 | -2 | 22 |
| 12 |
|
Martina | 18 | 5 | 6 | 7 | 24:28 | -4 | 21 |
| 13 |
|
Afragolese | 18 | 3 | 8 | 7 | 24:26 | -2 | 17 |
| 14 |
|
Sporting Fulgor Molfetta | 18 | 3 | 6 | 9 | 24:30 | -6 | 15 |
| 15 |
|
FC Francavilla | 18 | 3 | 6 | 9 | 17:23 | -6 | 15 |
| 16 |
|
FBC Gravina | 18 | 2 | 9 | 7 | 12:22 | -10 | 15 |
| 17 |
|
Lavello | 18 | 3 | 4 | 11 | 14:34 | -20 | 13 |
| 18 |
|
Puteolana Internapoli | 18 | 0 | 8 | 10 | 12:31 | -19 | 8 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
