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| 13.08.2021 | 17:00 | FK Panevėžys | - | FK Banga Gargždai | 3:1 (2:0) | |
| 15.08.2021 | 12:00 | FK Riteriai | - | FK Sūduva | 1:3 (0:0) | |
| 16:00 | Kauno Žalgiris | - | Hegelmann Litauen | 2:1 (0:0) | ||
| 14.10.2021 | 18:00 | FK Žalgiris | - | FK Nevėžis | 6:0 (3:0) | |
| 24.10.2021 | 16:00 | DFK Dainava | - | FC Džiugas | 3:2 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Žalgiris | 23 | 16 | 5 | 2 | 51:15 | 36 | 53 |
| 2 |
|
FK Sūduva | 23 | 14 | 4 | 5 | 39:20 | 19 | 46 |
| 3 |
|
Kauno Žalgiris | 23 | 12 | 7 | 4 | 40:25 | 15 | 43 |
| 4 |
|
FK Panevėžys | 23 | 12 | 6 | 5 | 34:25 | 9 | 42 |
| 5 |
|
Hegelmann Litauen | 23 | 9 | 5 | 9 | 35:26 | 9 | 32 |
| 6 |
|
FK Riteriai | 23 | 6 | 9 | 8 | 29:28 | 1 | 27 |
| 7 |
|
FC Džiugas | 23 | 6 | 6 | 11 | 28:34 | -6 | 24 |
| 8 |
|
FK Banga Gargždai | 23 | 6 | 2 | 15 | 24:49 | -25 | 20 |
| 9 |
|
DFK Dainava | 23 | 5 | 7 | 11 | 26:40 | -14 | 19 |
| 10 |
|
FK Nevėžis | 23 | 2 | 3 | 18 | 11:55 | -44 | 9 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
|
# 3 Punkte Abzug für DFK Dainava wegen Verstoßes gegen die Lizenzauflagen. |
