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| 23.07.2021 | 17:00 | FK Riteriai | - | FC Džiugas | 3:2 (1:0) | |
| 19:00 | FK Banga Gargždai | - | Hegelmann Litauen | 1:4 (0:4) | ||
| 25.07.2021 | 18:00 | FK Nevėžis | - | DFK Dainava | 0:1 (0:1) | |
| 25.08.2021 | 17:00 | FK Panevėžys | - | Kauno Žalgiris | 4:0 (1:0) | |
| 03.11.2021 | 17:00 | FK Sūduva | - | FK Žalgiris | 2:2 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Žalgiris | 29 | 18 | 8 | 3 | 62:23 | 39 | 62 |
| 2 |
|
FK Sūduva | 29 | 18 | 5 | 6 | 51:27 | 24 | 59 |
| 3 |
|
FK Panevėžys | 29 | 14 | 8 | 7 | 44:32 | 12 | 50 |
| 4 |
|
Kauno Žalgiris | 29 | 14 | 7 | 8 | 44:36 | 8 | 49 |
| 5 |
|
Hegelmann Litauen | 29 | 13 | 7 | 9 | 45:29 | 16 | 46 |
| 6 |
|
FK Riteriai | 29 | 9 | 11 | 9 | 40:33 | 7 | 38 |
| 7 |
|
FC Džiugas | 29 | 8 | 8 | 13 | 38:44 | -6 | 32 |
| 8 |
|
DFK Dainava | 29 | 8 | 7 | 14 | 35:49 | -14 | 28 |
| 9 |
|
FK Banga Gargždai | 29 | 7 | 4 | 18 | 33:61 | -28 | 25 |
| 10 |
|
FK Nevėžis | 29 | 2 | 3 | 24 | 12:70 | -58 | 9 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
|
# 3 Punkte Abzug für DFK Dainava wegen Verstoßes gegen die Lizenzauflagen. |
