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| H | FC Olimpia Bălți | - | FC Academia UTM | 2:0 (0:0) | ||
| R | FC Academia UTM | - | FC Olimpia Bălți | 0:1 (0:1) | ||
| H: 10.11.2010 13:00 | R: 24.11.2010 12:00 | Sieger: FC Olimpia Bălți | ||||
| H | FC Iskra-Stal | - | CSCA-Rapid Chişinău | 1:1 (0:0) | ||
| R | CSCA-Rapid Chişinău | - | FC Iskra-Stal | 0:2 (0:2) | ||
| H: 10.11.2010 13:00 | R: 24.11.2010 12:00 | Sieger: FC Iskra-Stal | ||||
| H | FC Tiraspol | - | FC Sheriff | 2:3 (2:1) | ||
| R | FC Sheriff | - | FC Tiraspol | 2:0 (2:0) | ||
| H: 10.11.2010 13:00 | R: 24.11.2010 12:00 | Sieger: FC Sheriff | ||||
| H | FC Cahul 2005 | - | Dacia Chişinău | 0:0 (0:0) | ||
| R | Dacia Chişinău | - | FC Cahul 2005 | 7:0 (3:0) | ||
| H: 10.11.2010 13:00 | R: 24.11.2010 17:00 | Sieger: Dacia Chişinău | ||||
