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| H | CF América | - | CF Pachuca | 0:0 (0:0) | ||
| R | CF Pachuca | - | CF América | 0:1 (0:1) | ||
| H: 30.11.2018 22:00 | R: 04.12.2018 01:00 | Sieger: CF América | ||||
| H | Deportivo Guadalajara | - | UANL Tigres | 1:1 (1:1) | ||
| R | UANL Tigres | - | Deportivo Guadalajara | 4:2 (3:2) | ||
| H: 01.12.2018 03:00 | R: 04.12.2018 03:00 | Sieger: UANL Tigres | ||||
