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| H | Deportivo Toluca | - | CF América | 2:2 (2:1) | ||
| R | CF América | - | Deportivo Toluca | 3:1 (3:1) | ||
| H: 22.11.2018 01:00 | R: 24.11.2018 22:00 | Sieger: CF América | ||||
| H | CF Monterrey | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| R | Deportivo Guadalajara | - | CF Monterrey | 0:0 (0:0) | ||
| H: 23.11.2018 02:00 | R: 26.11.2018 02:00 | Sieger: Deportivo Guadalajara | ||||
| H | Atlas Guadalajara | - | UANL Tigres | 1:2 (0:1) | ||
| R | UANL Tigres | - | Atlas Guadalajara | 0:0 (0:0) | ||
| H: 23.11.2018 18:00 | R: 27.11.2018 03:00 | Sieger: UANL Tigres | ||||
| H | Pumas UNAM | - | CF Pachuca | 0:1 (0:0) | ||
| R | CF Pachuca | - | Pumas UNAM | 5:1 (1:1) | ||
| H: 23.11.2018 22:00 | R: 27.11.2018 01:00 | Sieger: CF Pachuca | ||||
