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| 16.09.2022 | 18:30 | CF Monterrey | - | Deportivo Guadalajara | 0:2 (0:0) | |
| 17.09.2022 | 16:00 | CF Pachuca | - | Deportivo Toluca | 2:0 (1:0) | |
| 17:00 | Mazatlán FC | - | UANL Tigres | 0:3 (0:3) | ||
| 18:30 | Santos Laguna | - | Atlas Guadalajara | 2:0 (0:0) | ||
| 18:30 | Pumas UNAM | - | Club Necaxa | 2:1 (1:1) | ||
| 19:15 | FC Juárez | - | Gallos Blancos | 1:0 (1:0) | ||
| 19:45 | CF América | - | Cruz Azul | 1:1 (1:1) | ||
| 18.09.2022 | 18:45 | Atlético San Luis | - | Club León | 0:4 (0:3) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 12 | 10 | 1 | 1 | 28:12 | 16 | 31 |
| 2 |
|
CF Pachuca | 12 | 5 | 5 | 2 | 19:11 | 8 | 20 |
| 3 |
|
Club Necaxa | 11 | 6 | 1 | 4 | 19:7 | 12 | 19 |
| 4 |
|
Deportivo Toluca | 11 | 5 | 3 | 3 | 18:16 | 2 | 18 |
| 5 |
|
CF América | 11 | 4 | 3 | 4 | 22:19 | 3 | 15 |
| 6 |
|
Cruz Azul | 12 | 4 | 3 | 5 | 23:24 | -1 | 15 |
| 7 |
|
Gallos Blancos | 12 | 3 | 3 | 6 | 16:18 | -2 | 12 |
| 8 |
|
FC Juárez | 12 | 3 | 0 | 9 | 14:41 | -27 | 9 |
| 9 |
|
Puebla FC | 11 | 2 | 1 | 8 | 13:24 | -11 | 7 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 11 | 8 | 2 | 1 | 33:11 | 22 | 26 |
| 2 |
|
CF Monterrey | 11 | 6 | 4 | 1 | 29:15 | 14 | 22 |
| 3 |
|
Deportivo Guadalajara | 12 | 7 | 1 | 4 | 25:15 | 10 | 22 |
| 4 |
|
Club León | 12 | 6 | 1 | 5 | 22:13 | 9 | 19 |
| 5 |
|
Santos Laguna | 12 | 5 | 3 | 4 | 27:19 | 8 | 18 |
| 6 |
|
UANL Tigres | 11 | 5 | 2 | 4 | 17:20 | -3 | 17 |
| 7 |
|
Atlas Guadalajara | 11 | 4 | 3 | 4 | 22:17 | 5 | 15 |
| 8 |
|
Atlético San Luis | 12 | 2 | 0 | 10 | 13:48 | -35 | 6 |
| 9 |
|
Mazatlán FC | 12 | 1 | 0 | 11 | 11:41 | -30 | 3 |
| Playoffs | |
| Playoffs |
