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| 24.09.2022 | 18:00 | UANL Tigres | - | Atlético San Luis | 5:2 (2:0) | |
| 18:30 | Club Necaxa | - | CF Pachuca | 0:0 (0:0) | ||
| 18:30 | Cruz Azul | - | Puebla FC | 1:1 (1:1) | ||
| 18:30 | Deportivo Toluca | - | FC Juárez | 7:1 (3:0) | ||
| 18:30 | Atlas Guadalajara | - | Mazatlán FC | 3:1 (2:0) | ||
| 18:30 | Gallos Blancos | - | CF América | 0:1 (0:1) | ||
| 18:30 | Club León | - | CF Monterrey | 2:2 (0:0) | ||
| 25.09.2022 | 18:15 | Deportivo Guadalajara | - | Club Tijuana | 2:1 (1:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 12 | 10 | 1 | 1 | 28:12 | 16 | 31 |
| 2 |
|
Deportivo Toluca | 12 | 6 | 3 | 3 | 25:17 | 8 | 21 |
| 3 |
|
CF Pachuca | 13 | 5 | 6 | 2 | 19:11 | 8 | 21 |
| 4 |
|
Club Necaxa | 12 | 6 | 2 | 4 | 19:7 | 12 | 20 |
| 5 |
|
CF América | 12 | 5 | 3 | 4 | 23:19 | 4 | 18 |
| 6 |
|
Cruz Azul | 13 | 4 | 4 | 5 | 24:25 | -1 | 16 |
| 7 |
|
Gallos Blancos | 13 | 3 | 3 | 7 | 16:19 | -3 | 12 |
| 8 |
|
FC Juárez | 13 | 3 | 0 | 10 | 15:48 | -33 | 9 |
| 9 |
|
Puebla FC | 12 | 2 | 2 | 8 | 14:25 | -11 | 8 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 12 | 8 | 2 | 2 | 34:13 | 21 | 26 |
| 2 |
|
Deportivo Guadalajara | 13 | 8 | 1 | 4 | 27:16 | 11 | 25 |
| 3 |
|
CF Monterrey | 12 | 6 | 5 | 1 | 31:17 | 14 | 23 |
| 4 |
|
Club León | 13 | 6 | 2 | 5 | 24:15 | 9 | 20 |
| 5 |
|
UANL Tigres | 12 | 6 | 2 | 4 | 22:22 | 0 | 20 |
| 6 |
|
Santos Laguna | 12 | 5 | 3 | 4 | 27:19 | 8 | 18 |
| 7 |
|
Atlas Guadalajara | 12 | 5 | 3 | 4 | 25:18 | 7 | 18 |
| 8 |
|
Atlético San Luis | 13 | 2 | 0 | 11 | 15:53 | -38 | 6 |
| 9 |
|
Mazatlán FC | 13 | 1 | 0 | 12 | 12:44 | -32 | 3 |
| Playoffs | |
| Playoffs |
