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| H | TM Fútbol Club | - | Dorados de Sinaloa | 1:0 (1:0) | ||
| R | Dorados de Sinaloa | - | TM Fútbol Club | 0:1 (0:1) | ||
| H: 09.12.2021 01:30 | R: 12.12.2021 04:00 | Sieger: TM Fútbol Club | ||||
| H | Club Celaya | - | Atlante | 0:1 (0:1) | ||
| R | Atlante | - | Club Celaya | 2:2 (0:0) | ||
| H: 10.12.2021 01:30 | R: 12.12.2021 19:00 | Sieger: Atlante | ||||
