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| H | Club Irapuato | - | Inter Playa | 0:0 (0:0) | ||
| R | Inter Playa | - | Club Irapuato | 1:2 (1:1) | ||
| H: 30.04.2021 03:00 | R: 02.05.2021 23:00 | Sieger: Club Irapuato | ||||
| H | Alacranes de Durango | - | Cruz Azul Hidalgo | 1:1 (1:1) | ||
| R | Cruz Azul Hidalgo | - | Alacranes de Durango | 1:1 (1:1) | ||
| H: 30.04.2021 03:30 | R: 02.05.2021 23:00 | |||||
