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| H | CF América | - | CF Monterrey | 0:0 (0:0) | ||
| R | CF Monterrey | - | CF América | 2:0 (1:0) | ||
| H: 10.05.2012 04:00 | R: 13.05.2012 04:00 | Sieger: CF Monterrey | ||||
| H | UANL Tigres | - | Santos Laguna | 1:1 (0:0) | ||
| R | Santos Laguna | - | UANL Tigres | 2:2 (0:2) | ||
| H: 11.05.2012 03:00 | R: 14.05.2012 03:00 | Sieger: UANL Tigres | ||||
