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| H | Cruz Azul | - | Club León | 2:1 (1:0) | ||
| R | Club León | - | Cruz Azul | 3:0 (2:0) | ||
| H: 15.11.2012 02:00 | R: 18.11.2012 02:00 | Sieger: Club León | ||||
| H | Monarcas Morelia | - | CF América | 0:2 (0:0) | ||
| R | CF América | - | Monarcas Morelia | 1:2 (1:2) | ||
| H: 15.11.2012 04:00 | R: 18.11.2012 00:00 | Sieger: CF América | ||||
| H | CF Monterrey | - | Club Tijuana | 0:1 (0:0) | ||
| R | Club Tijuana | - | CF Monterrey | 1:1 (0:0) | ||
| H: 16.11.2012 02:00 | R: 19.11.2012 01:30 | Sieger: Club Tijuana | ||||
| H | Deportivo Guadalajara | - | Deportivo Toluca | 1:2 (0:2) | ||
| R | Deportivo Toluca | - | Deportivo Guadalajara | 3:1 (0:0) | ||
| H: 16.11.2012 04:00 | R: 18.11.2012 19:00 | Sieger: Deportivo Toluca | ||||
