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| H | CF Monterrey | - | UANL Tigres | 1:0 (1:0) | ||
| R | UANL Tigres | - | CF Monterrey | 1:1 (1:1) | ||
| H: 09.05.2013 02:00 | R: 12.05.2013 02:00 | Sieger: CF Monterrey | ||||
| H | Pumas UNAM | - | CF América | 0:1 (0:1) | ||
| R | CF América | - | Pumas UNAM | 2:1 (0:1) | ||
| H: 09.05.2013 04:00 | R: 12.05.2013 00:00 | Sieger: CF América | ||||
| H | Santos Laguna | - | Atlas Guadalajara | 0:0 (0:0) | ||
| R | Atlas Guadalajara | - | Santos Laguna | 1:3 (1:1) | ||
| H: 10.05.2013 02:00 | R: 13.05.2013 03:00 | Sieger: Santos Laguna | ||||
| H | Cruz Azul | - | Monarcas Morelia | 4:2 (1:1) | ||
| R | Monarcas Morelia | - | Cruz Azul | 1:0 (1:0) | ||
| H: 10.05.2013 04:00 | R: 13.05.2013 01:00 | Sieger: Cruz Azul | ||||
