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| H | Gallos Blancos | - | Cruz Azul | 0:2 (0:1) | ||
| R | Cruz Azul | - | Gallos Blancos | 1:1 (1:0) | ||
| H: 29.11.2018 02:00 | R: 02.12.2018 02:00 | Sieger: Cruz Azul | ||||
| H | CF Monterrey | - | Santos Laguna | 1:0 (0:0) | ||
| R | Santos Laguna | - | CF Monterrey | 0:2 (0:0) | ||
| H: 29.11.2018 04:06 | R: 02.12.2018 04:00 | Sieger: CF Monterrey | ||||
| H | Deportivo Toluca | - | CF América | 2:2 (1:2) | ||
| R | CF América | - | Deportivo Toluca | 3:2 (2:0) | ||
| H: 30.11.2018 02:00 | R: 03.12.2018 01:30 | Sieger: CF América | ||||
| H | UANL Tigres | - | Pumas UNAM | 2:1 (0:1) | ||
| R | Pumas UNAM | - | UANL Tigres | 3:1 (0:0) | ||
| H: 30.11.2018 04:00 | R: 02.12.2018 19:00 | Sieger: Pumas UNAM | ||||
