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| H | CF Pachuca | - | Cruz Azul | 0:0 (0:0) | ||
| R | Cruz Azul | - | CF Pachuca | 1:0 (0:0) | ||
| H: 20.05.2021 03:30 | R: 23.05.2021 03:00 | Sieger: Cruz Azul | ||||
| H | Santos Laguna | - | Puebla FC | 3:0 (2:0) | ||
| R | Puebla FC | - | Santos Laguna | 1:0 (0:0) | ||
| H: 21.05.2021 04:00 | R: 24.05.2021 02:00 | Sieger: Santos Laguna | ||||
